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Basic information

CohesinDB ID: CDBP00421133

Locus: chr21-44876848-44922035

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, TF-1, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, GM19099, HL-60, A-549, GM19238, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 82% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.122

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 20%, "14_ReprPCWk": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, HMG20A, MEIS2, FOXA1, HLF, RBFOX2, RXRB, UBTF, PBX2, TFAP4, HDGF, ATF3, NFIC, THRB, ATF4, MXD4, MECOM, SMARCE1, CDX2, JMJD1C, KLF5, ELF1, TRIM28, TEAD1, KLF6, RCOR2, ESR1, HNF1B, HDAC8, USF2, CTCF, TCF12, JUN, EP300, E4F1, KLF1, MNT, ZNF157, SOX5, PYGO2, DPF2, TRIM24, SOX6, E2F4, CREB3, E2F1, RFX3, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, GTF2F1, RBPJ, EED, MLX, POU5F1, CTBP1, MTA2, DUX4, STAT1, SRF, GATAD1, SAP130, NBN, MLLT3, ARID3A, TBP, HNF4G, ERG, HOXC5, SMARCC2, ETS1, MYC, ONECUT1, SMARCA4, HOMEZ, RAD21, ARID1B, RXRA, PROX1, FOXK2, GABPA, MCRS1, STAT3, ZNF614, XRCC5, IKZF1, MIER3, LEF1, NR2F6, NFRKB, RCOR1, NFE2, DNMT3B, CEBPB, ESRRA, KMT2A, CREB1, CCAR2, TBL1XR1, GRHL2, ZNF652, GABPB1, PHF8, ZHX2, SPI1, TFE3, MIXL1, EHF, IRF1, HBP1, HDAC2, SSRP1, INTS13, ZNF644, GATA2, DRAP1, ZGPAT, NR2C2, RELB, NFIL3, NFYB, EP400, ATF1, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, HDAC1, SOX13, SIN3A, AFF4, SMAD3, TBX3, SP5, ZMIZ1, SMARCC1, MYBL2, RARA, ZNF35, PRPF4, NFYC, CREBBP, BRD9, GATA4, ARNT, BACH1, PBX4, DAXX, ZNF48, SMAD4, ZEB2, SATB1, HMBOX1, FOXM1, NR2C1, FOS, HMGXB4, CDK8, MED1, ZNF584, TEAD3, ZEB1, CEBPD, PML, L3MBTL2, EVI1, MBD1, RBM22, SP1, BCL11A, HNF4A, IKZF5, REST, ARID1A, ZBTB7A, ATF7, ZHX1, ASH2L, AFF1, BCOR, FOXP1, TCF3, MLLT1, STAG1, ETV4, NFATC3, PTTG1, SKI, MEF2B, PPARG, FOXA2, MTA3, CREM, RBBP5, CBX3, E2F8, MIER2, CHD2, MAFF, ZBTB33, MEF2C, CDK9, HOXB13, ZNF580, KDM1A, YY1, ZNF589, CREB3L1, RELA, ZNF148, JUNB, NEUROD1, HIF1A, GATA3, MGA, MAX, SPIB, GATA1, MTA1, CEBPG, ZNF592, KLF4, NCOA3, NR2F2, GFI1B, NR2F1, KDM5B, TP53, PKNOX1, NFKB1, ELF3, PHF5A, KAT8, ARID4B, NFKBIZ, BHLHE40, AR, ZBTB40, EGR1, ZBTB26, RNF2, IKZF2, BRD4, JUND, ILF3, NCOR1, CUX1, MAZ, ZNF24, DMAP1, FOSL2

Target gene symbol (double-evidenced CRMs): TRAPPC10,UBE2G2,PTTG1IP,PFKL,CFAP410,FAM207A,ITGB2-AS1,TRPM2,TSPEAR,SUMO3,ITGB2,WDR4,ADARB1

Function elements

Human SNPs: Gamma_glutamyl_transferase_levels

Number of somatic mutations (coding): 5498

Number of somatic mutations (non-coding): 825

Related genes and loops

Related gene: ENSG00000160193, ENSG00000160218, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381,

eachgene

Deatailed information for cohesin site CDBP00421133