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Basic information

CohesinDB ID: CDBP00421139

Locus: chr21-44956348-44960682

Data sourse: ENCSR230ZWH, GSE67783, GSE86191, GSE165895, GSE116868, GSE111913, ENCSR000BLY, ENCSR000EHW, GSE101921, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, ENCSR000EHX, ENCSR635OSG, GSE130135, GSE116344, GSE131606, GSE83726, GSE94872, ENCSR917QNE

Cell type: RPE, Fibroblast, HCT-116, RH4, HEK293T, MB157, HUVEC, HCAEC, RT-112, HSPC, SK-N-SH, K-562, Liver, HFFc6, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 9% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.833

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 81% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 32%, "5_TxWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, HLF, MLL4, HDGF, THAP1, TEAD1, LMO2, PITX3, HDAC8, DEK, E2F4, KMT2B, GATAD2A, JARID2, ZNF263, POU5F1, TOP2A, CTBP1, ZMYND11, DUX4, STAT1, SAP130, ERG, ZBTB8A, SMARCA4, RFX1, FOXK2, RCOR1, NR2F6, DACH1, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, EP400, RUNX1, CEBPA, HDAC1, TET2, SMARCC1, PRDM10, ZBTB2, ATF2, SP2, SMARCB1, GMEB1, PML, NR1H2, C11orf30, EVI1, MBD1, STAT5A, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, PAF1, SS18, WT1, MEF2C, JUNB, NEUROD1, TCF4, ZFP36, PLAG1, KLF4, ZNF281, MED, EGR2, ARID4B, RXR, HSF1, NCOR1, ZBTB26, SCRT1, ZNF316, FOSL1, XBP1, PBX2, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, ZNF467, JMJD1C, MAF, INTS11, ELF1, RBM39, SNAI2, CTCF, JUN, LMO1, MNT, DPF2, ZNF423, RBPJ, TFAP2C, ZNF317, MTA2, ZBTB48, SRF, PPARGC1A, CHD4, PBX1, FOXP2, RXRA, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, STAT5B, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, NFIL3, THAP11, EZH2phosphoT487, LDB1, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ARNT, ZNF48, PRDM9, ZEB2, ETV6, PBX3, NCAPH2, ZNF10, TEAD3, KLF9, TBX5, USF1, SP1, BCL11A, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, ZNF143, AGO2, CBX2, TP53, ZNF334, NFKB1, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, IRF9, PGR, SOX2, PATZ1, LEO1, TFAP4, CHD7, ATF4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, SP4, HNF4G, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, SPI1, PCBP1, HDAC2, INTS13, TAF9B, ZNF490, NFYB, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, MYBL2, RARA, ZNF35, CREBBP, ZNF384, TAF15, ZNF133, SMAD4, CBFA2T3, CDK8, ZEB1, NCOA1, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, ZNF692, GTF2B, ZNF662, ZNF318, RELA, TARDBP, ZNF282, MAX, ZNF592, GFI1B, NEUROG2, NR2F1, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, ZBTB16, HEXIM1, AHR, FOSL2, DMAP1, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, SFMBT1, LYL1, NFIC, CTCFL, PRDM1, MECOM, ZNF736, CDX2, TRIM28, MLL, USF2, TCF12, EP300, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, RAD21, GRHL3, APC, XRCC5, NFE2, TCF25, ZNF639, ARNTL, ZNF750, HBP1, IRF1, MRTFB, ATF1, PTBP1, MAFG, SMC1A, SIRT6, FIP1L1, ZFX, SMAD3, TWIST1, NSD2, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, GR, PBX4, NRF1, ZNF708, NR2C1, CHD1, SUPT5H, FOS, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF3, SETDB1, ZBTB7A, CCNT2, TCF3, PAX7, SKI, FOXA2, RBBP5, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, BRCA1, SP140, HIF1A, OTX2, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, MYNN, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): POFUT2,PTTG1IP,FAM207A,PCBP3,ADARB1,COL18A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 66

Number of somatic mutations (non-coding): 8

Related genes and loops

Related gene: ENSG00000183255, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421139