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Basic information

CohesinDB ID: CDBP00421142

Locus: chr21-44974593-45005352

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE131606, GSE108869, GSE25021, GSE115602, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE206145, ENCSR000EHX, ENCSR767DFK, GSE97394, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: RH4, CVB-hiPSC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, HEKn, Ishikawa, GM12890, HeLa-S3, IMR-90, BCBL-1, K-562, DKO, HFFc6, H1-hESC, Monocytes, MB157, GM12891, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 27% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.578

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 25%, "5_TxWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, ATF3, MYCN, ZHX2, NR2F1, HSF1, BRD4, ZBTB48, LEO1, AATF, ZBTB33, TP63, RBM22, AGO2, DNMT3B

Target gene symbol (double-evidenced CRMs): ADARB1,PCBP3,COL18A1,COL6A2,POFUT2,TSPEAR,SLC19A1,PTTG1IP,FAM207A,ITGB2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 74

Number of somatic mutations (non-coding): 249

Related genes and loops

Related gene: ENSG00000175894, ENSG00000183255, ENSG00000160255, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421142