- Basic information
- CohesinDB ID: CDBP00421144
- Locus: chr21-45008165-45008852
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Data sourse: GSE206145, GSE116344, GSE206145-NatGen2015, GSE86191
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Cell type: RPE, RH4, Fibroblast, HCT-116
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: Rad21,SA2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 41%,
"14_ReprPCWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, THAP1, MORC2, PAX5, ZNF320, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, SOX5, PAX8, DEK, E2F4, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB21, PAX6, EZH1, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, HCFC1R1, RUNX1, CEBPA, HDAC1, CRY1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PIAS1, SMAD1, NR1H2, C11orf30, MBD1, STAT5A, IKZF5, ARID2, ZNF605, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, PAF1, SS18, NFATC1, WT1, NEUROD1, JUNB, MCM3, TCF4, ZFP36, MAF1, PLAG1, KLF4, ZFP69B, BCL11B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, SCRT1, ZNF316, FOSL1, ZNF621, XBP1, HNF1A, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, CBFB, TP63, ZSCAN4, MITF, CDC5L, MAF, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, TAF3, L3MBTL4, MNT, LMO1, DPF2, RYBP, ZNF423, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, ZNF317, ZSCAN21, NONO, SRF, DDX5, PBX1, ONECUT1, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, TERF2, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, SMARCA5, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, SP3, ARNT, DAXX, BACH1, ZNF48, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, ZNF680, U2AF1, KLF9, TBX5, USF1, BCL11A, SP1, TFAP2A, NKX2-5, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, CBX2, ZNF141, TP53, ZNF334, NFKB1, PHF5A, BRD2, KAT8, EGR1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZNF468, PGR, SOX2, PATZ1, LEO1, UBTF, RING1B, SMAD1-5, TFAP4, SIN3B, ZNF112, BMI1, CHD7, MXD4, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, ZSCAN5A, ELK4, ERG2, HIC1, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, KLF12, NKX2-1, MCRS1, GABPA, STAT3, SOX10, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, ZNF436, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ZFP37, ERG3, RARA, NFYC, CREBBP, ZNF384, TAF15, SMAD4, CDK8, ZEB1, ZNF264, ZMYM3, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, PPARG, ZNF692, GTF2B, ZNF30, ZNF662, TCF7, FOXO3, RELA, TARDBP, MGA, MAX, ZNF223, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, YAP1, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF90, NFIC, CTCFL, ZBTB5, PRDM1, KLF14, ZNF736, CDX2, ZNF629, KLF5, TRIM28, ETV1, RCOR2, COBLL1, HNF1B, USF2, TCF12, EP300, BAF155, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, GATAD1, ARID3A, ASCL1, ZNF341, MCM5, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, TCF25, ARNTL, ZNF750, TFE3, HBP1, EHF, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, CBX8, TWIST1, PRPF4, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, FOS, CHD1, SUPT5H, TGIF2, MED1, KDM6B, CEBPD, SCRT2, MYB, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, PHIP, TCF3, SKI, PAX7, NELFA, KLF13, FOXA2, RBBP5, ZNF600, MIER2, FOXF1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, NFKBIZ, BHLHE40, TAF1, MYNN, CLOCK, MAZ
- Target gene symbol (double-evidenced CRMs): ADARB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops