- Basic information
- CohesinDB ID: CDBP00421150
- Locus: chr21-45039708-45043312
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Data sourse: ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE116868, ENCSR000ECS, GSE103477, GSE111537, GSE25021, GSE108869, ENCSR917QNE, ENCSR000EFJ, GSE67783, GSE86191, GSE138405, GSE206145-NatGen2015, GSE120943, GSE98367, GSE206145, ENCSR981FDC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR000HPG, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE126755, ENCSR748MVX
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Cell type: Liver, HuCC-T1, RPE, Fibroblast, HeLa-S3, Neutrophil, IMR-90, K-562, Monocytes, MB157, RT-112, THP-1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.778
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 33%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, TRIM25, PGR, ZSCAN5D, ZNF621, MEIS2, XBP1, FOXA1, HLF, SUZ12, RXRB, PBX2, ZNF28, ZFHX2, KDM3A, ZBTB7B, KDM4C, HDGF, ATF3, THRB, BMI1, INSM2, ZBTB5, PRDM1, ZNF444, CBFB, TP63, ZSCAN4, CDC5L, ZNF467, JMJD1C, KLF5, ELF1, BCLAF1, TRIM28, ETV1, RBM39, NFE2L2, ESR1, MLL, OCA2, ZIK1, CTCF, JUN, TCF12, EP300, E4F1, DPF2, TRIM24, RFX5, ZNF407, GLI4, DEK, E2F4, RAD51, ZNF410, ZNF398, ZNF512B, ZNF280A, KMT2B, ZNF175, GATAD2A, EHMT2, RBPJ, TFAP2C, PLRG1, GLIS1, YBX1, POU2F2, CHD8, BRD1, NANOG, MYCN, ZNF263, TOP2A, ZNF239, POU5F1, CTBP1, MTA2, ASH1L, ZBTB48, ZSCAN5A, STAT1, ZSCAN21, NONO, SRF, ZBTB1, SAP130, DDX5, ERG2, PHB2, NBN, ARID3A, ZNF300, ERG, OGG1, MIER1, ETS1, MYC, SMARCA4, RFX1, RAD21, GRHL3, FOXK2, STAT3, XRCC5, UBN1, ZNF8, PRDM14, IKZF1, RCOR1, DNMT3B, NR2F6, NFE2, VDR, HNRNPH1, NR3C1, CEBPB, SRSF3, ZNF639, HNRNPL, LEF1, KMT2A, CREB1, YBX3, ESRRA, EZH2, ARHGAP35, BMPR1A, EBF3, GABPB1, SPI1, HES1, IRF1, PCBP1, HDAC2, GATA2, SSRP1, GATAD2B, MXD3, ZNF146, FLI1, ZGPAT, MXI1, SMARCA5, ZNF785, ATM, HCFC1R1, NCOA2, PTBP1, SALL2, RUNX1, BCL6, SMC1A, CEBPA, HDAC1, ZNF707, CRY1, AFF4, ZFX, ZBTB24, SMAD3, ZNF770, TET2, ERG3, NFXL1, ZNF473, CBX8, SMARCC1, TWIST1, ZNF18, RARA, ZNF384, ZBTB2, TAF15, RUNX2, CDK6, ZNF184, GR, ARNT, NFIB, PBX4, ZNF48, SNIP1, SMAD4, ATF2, PBX3, CHD1, SMARCB1, CDK8, FOS, MED1, TEAD3, ZEB1, ZNF670, MYB, SCRT2, KDM6B, ZNF3, NCOA1, SETDB1, STAT5A, BCL11A, SP1, PHF20, IKZF5, ARID2, ZBTB7A, ZNF479, REST, ZHX1, ATF7, HNRNPLL, BCOR, GLIS2, SALL1, TCF3, AATF, SMC3, STAG1, MLLT1, STAG2, TRP47, CBFA2T2, NCOA4, ZNF316, AGO1, FOXA2, EBF1, CHD2, ZNF207, NFATC1, MTA3, GTF2B, WT1, MAFF, ZNF662, MEF2C, ZBTB33, CDK9, ZNF580, ZKSCAN1, BCL3, KDM1A, YY1, RELA, HOXB13, TARDBP, NEUROD1, ZNF148, ZNF521, MCM3, SP140, ZIC2, ZFP36, HIF1A, ZNF311, TAL1, MAF1, MAX, NRIP1, ZNF143, MTA1, HAND2, PLAG1, CBX2, CEBPG, ZNF592, NCOA3, NR2F2, ZNF544, NR2F1, ZNF791, KDM5B, ZNF687, PKNOX1, TP53, ZNF334, NFKB1, BCL6B, EGR2, RBM14, BHLHE40, AR, TAF1, ZBTB40, RXR, HEXIM1, TFIIIC, HSF1, ZBTB26, NCOR1, BRD4, SCRT1, JUND, CLOCK, RNF2, MAZ, ZSCAN23, TBX2, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): PCBP3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 32
- Related genes and loops