- Basic information
- CohesinDB ID: CDBP00421156
- Locus: chr21-45048450-45052737
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE105028, GSE108869, GSE165895, ENCSR000EFJ, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE206145-NatGen2015, GSE112028, ENCSR703TNG, ENCSR895JMI, GSE206145, ENCSR807WAC, ENCSR495WGO, ENCSR853VWZ, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, ENCSR000ECS
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, A-549, HeLa-S3, RT-112, IMR-90, HSPC, K-562, HeLa-Tet-On, HFFc6, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 30%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, CBX5, PGR, CBX3, CEBPA, ZFX, ZNF600, ZNF317, HLF, ZNF134, CBX8, ZNF18, ERG, RELA, ZNF384, JUNB, ATF3, NFIC, MYC, RUNX2, RUNX3, SP140, MAX, ZNF10, MED1, CBX2, CEBPG, CEBPB, NR3C1, TEAD1, TRIM28, CEBPD, NR2F2, SETDB1, ZNF577, CTCF, SPI1, TRIM24, RNF2, BRD4, ZNF440
- Target gene symbol (double-evidenced CRMs): PCBP3,ADARB1,TSPEAR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 38
- Related genes and loops