- Basic information
- CohesinDB ID: CDBP00421158
- Locus: chr21-45053553-45057282
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000EGW, GSE111537, GSE25021, GSE108869, ENCSR330ELC, GSE67783, GSE86191, GSE101921, GSE206145-NatGen2015, GSE120943, GSE116344, GSE98367, GSE206145, ENCSR956LGB, ENCSR335RKQ, ENCSR054FKH, ENCSR153HNT, ENCSR481YWD
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, Monocytes, Hep-G2, MB157, RH4, A-549, HCAEC, HeLa-S3, K-562, Liver, OCI-AML-3, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 33%,
"7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, MEIS2, NME2, XBP1, FOXA1, SUZ12, RXRB, PBX2, MLL4, ATF3, NFIC, THRB, ZFP64, THAP1, ZBTB5, SETX, RUNX3, CHD7, CBFB, MORC2, MXD4, MECOM, PAX5, TP63, MITF, ZNF736, SFPQ, ZNF467, ELF1, TEAD1, ZNF121, KLF6, TRIM28, NFE2L2, RBM39, ESR1, OCA2, USF2, CTCF, TCF12, JUN, EP300, BAF155, KLF1, MNT, SND1, SOX5, GATA6, DPF2, SOX4, E2F6, IRF4, RFX5, TRIM24, DEK, SMC1, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, TFAP2C, EED, JARID2, NANOG, CHD8, BRD1, ZSCAN5D, MYCN, POU5F1, TOP2A, KDM4C, ZNF263, POU2F2, ZBTB17, ZBTB48, STAT1, ELK4, SRF, TBP, ERG, OGG1, ETS1, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, ZNF614, XRCC5, UBN1, PRDM14, NKX3-1, MIER3, RCOR1, APC, DNMT3B, VDR, NR3C1, CEBPB, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, FEZF1, ZNF652, EBF3, MRTFA, GABPB1, PHF8, ZHX2, HDAC2, GATA2, ZNF182, MXD3, FLI1, SREBF1, MXI1, NR2C2, MRTFB, NCOA2, ETV5, PTBP1, RUNX1, SMC1A, BCL6, CEBPA, EZH2phosphoT487, NKX2-2, CRY1, AFF4, ZFX, SIN3A, POU4F2, SOX13, SMAD3, FIP1L1, TET2, ZNF770, ERG3, SMARCC1, RARA, CREBBP, ZNF384, RUNX2, CDK6, NRF1, ARNT, DAXX, PBX4, ZNF48, PRDM9, SMAD4, HMGB2, FOXM1, NCAPH2, NR2C1, CHD1, SMARCB1, FOS, CDK8, ZNF10, MED1, CBFA2T3, CSNK2A1, TEAD3, KDM6B, SCRT2, PIAS1, SUPT16H, ZNF3, NCOA1, TBX5, SREBF2, SETDB1, USF1, MAFK, SP1, BCL11A, HNF4A, IKZF5, REST, ZBTB7A, ZNF479, ZHX1, ASH2L, HNRNPLL, CTBP2, BCOR, FOXP1, TCF3, AATF, SMC3, ELL2, NCOR2, STAG1, STAG2, TRP47, CBFA2T2, FOXA2, AGO1, CHD2, MEIS1, ZNF600, GTF2B, WT1, MAFF, MEF2C, CDK9, ZNF580, BCL3, HOXB13, KDM1A, YY1, RELA, ZKSCAN1, NEUROD1, JUNB, MCM3, SP140, ZIC2, HIF1A, ZNF611, ZFP36, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, CBX2, PLAG1, TLE3, NCOA3, NR2F2, NR2F1, NEUROG2, TCF7L2, KDM5B, TP53, MED, ZNF334, MYOD1, PHOX2B, T, BRD2, ARRB1, ARID4B, AR, BHLHE40, TAF1, YAP1, RXR, EGLN2, HEXIM1, EGR1, TFIIIC, HSF1, ZBTB26, NOTCH3, BRD4, JUND, RB1, CLOCK, CUX1, MAZ, BRCA1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): TSPEAR,ADARB1,FAM207A
- Function elements
- Human SNPs: Metabolite_levels
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 28
- Related genes and loops