- Basic information
- CohesinDB ID: CDBP00421166
- Locus: chr21-45067286-45068242
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Data sourse: GSE143937, ENCSR000BKV, ENCSR000FAD, ENCSR000EGW, ENCSR000BLY, ENCSR879KXD, ENCSR000EHW, ENCSR000EHX, ENCSR153HNT, GSE73207
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Cell type: K-562, TF-1, SK-N-SH
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 4% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: SMC3,Rad21,SA1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 50%,
"14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, HMGN3, MEIS2, FOXA1, PBX2, UBTF, ATF3, NFIC, HNRNPUL1, ZBTB5, ATF4, MORC2, SMARCE1, MITF, HDAC3, RLF, ELF1, TRIM28, ETV1, RBM39, NFE2L2, PITX3, HDAC8, USF2, CTCF, TCF12, JUN, EP300, E4F1, MNT, PYGO2, DPF2, E2F6, TRIM24, ZNF407, SOX6, CREB3, RAD51, E2F1, TEAD4, ZNF175, GTF2F1, EHMT2, GATAD2A, MYCN, ZNF263, TOP2A, ID3, CTBP1, MTA2, ZBTB17, ZBTB48, STAT1, NONO, NBN, ARID3A, PHB2, TBP, ERG, SMARCC2, ETS1, MYC, ZNF341, SMARCA4, ARID1B, RAD21, FOXK2, GABPA, XRCC5, IKZF1, LEF1, RCOR1, ZNF639, DACH1, NR2F6, NFE2, NR3C1, CEBPB, ESRRA, CREB1, ZBTB11, EZH2, TBL1XR1, EBF3, SPI1, HES1, ZNF257, HDAC2, GATA2, ZNF644, ZSCAN29, TAF9B, FLI1, HCFC1, MXI1, ATF1, CC2D1A, RUNX1, HDAC1, SIRT6, LDB1, NKX2-2, ZFX, ZNF770, ZMIZ1, TWIST1, PRDM10, ZBTB2, ZNF384, ZNF35, ARNT, BACH1, ELK1, ATF2, PRDM9, ZEB2, HMBOX1, ETV6, CBFA2T3, ZNF10, FOXM1, CDK8, SMARCB1, NR2C1, MED1, ZNF584, GMEB1, PML, DIDO1, CEBPD, MYB, SMAD1, VEZF1, NCOA1, L3MBTL2, STAT5A, KLF16, USF1, BCL11A, NR4A1, REST, ZBTB7A, CCNT2, ATF7, AFF1, BCOR, MBD2, SMC3, MLLT1, STAG1, NFATC3, CBFA2T2, KLF13, CBX3, MTA3, CREM, RBBP5, CHD2, ZNF600, ZBED1, WT1, ZBTB33, ZKSCAN1, ZNF318, KDM1A, ZNF589, RELA, FOXO3, TARDBP, YY1, JUNB, NEUROD1, CHAMP1, ZNF282, ISL1, SP140, ZFP36, SKIL, GATA3, TAL1, MAX, GATA1, MTA1, ZNF143, HAND2, PLAG1, SP7, GFI1B, NR2F2, ZKSCAN8, ZNF83, NR2F1, PKNOX1, ZBTB6, PHOX2B, BHLHE40, TAF1, ZBTB40, EGR1, MYNN, RNF2, NCOR1, JUND, ILF3, BRD4, MAZ, TBX2, MEF2D, ZNF24, ZNF395
- Target gene symbol (double-evidenced CRMs): ADARB1,TSPEAR
- Function elements
- Human SNPs: Educational_attainment_(years_of_education)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops