Deatailed information for cohesin site CDBP00421168

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00421168
  • Locus: chr21-45070965-45077708
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR501LQA, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE121355, GSE111537, GSE131606, GSE108869, GSE25021, GSE115602, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000EAC, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE93080, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE76815, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR981FDC, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR748MVX, ENCSR767DFK, GSE206145, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411
  • Cell type: RH4, CVB-hiPSC, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM2588, SK-N-SH, RT-112, HeLa-Tet-On, Macrophage, MCF-7, GM12892, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, Neutrophil, HAP1
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 41% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.467
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 85% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 20%, "1_TssA": 17%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, SRSF7, MORC2, PAX5, TEAD1, SNAPC1, ZNF121, LMO2, OCA2, MED26, PITX3, ZNF561, ZNF507, E4F1, SOX5, DEK, E2F4, ZNF410, NR5A2, ZNF528, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, ZMYND11, STAT1, SAP130, ERG, PAX6, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, KLF17, GATA2, MXD3, FLI1, HCFC1, DRAP1, MXI1, ZNF785, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, IRF3, CRY1, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, ELK1, TFDP1, ZBTB10, ATF2, SNIP1, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, STAT5A, ARID2, IKZF5, RBM25, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, ZFP36, MAF1, PLAG1, ZFP69B, KLF4, BCL11B, ZBTB6, EGR2, ZNF765, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, KDM4B, PBX2, ZNF596, HNRNPK, TSC22D4, ATF3, ZFP64, HNRNPUL1, WDHD1, CBFB, TP63, MITF, CDC5L, ZNF467, INTS11, JMJD1C, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, L3MBTL4, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, ZNF776, ZNF677, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, UTX, SRF, NONO, DDX5, NBN, ONECUT1, KDM4A, HOMEZ, FOXP2, ZNF2, NKX3-1, PRDM14, LEF1, HNRNPH1, MIER3, VDR, NR3C1, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, ARHGAP35, GRHL2, EBF3, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, ARNT, NFIB, BACH1, ZNF48, ZEB2, HMBOX1, NFYA, PBX3, MAFB, NCAPH2, ETV6, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, BCL11A, TFAP2A, SP1, NKX2-5, ZNF479, ATF7, ASH2L, CTBP2, PCGF2, GLIS2, PRDM6, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF441, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, NFKB1, ZSCAN22, PHF5A, BRD2, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, PRDM2, CUX1, ZSCAN23, TBX2, ZNF468, PGR, FANCL, PATZ1, RING1B, UBTF, LEO1, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, SND1, KLF1, SOX9, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, HIC1, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, PHF21A, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, SRSF3, EZH2, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF777, NCOA2, ZNF76, ETV5, GTF2A2, BCL6, SIN3A, ZFP37, ERG3, NFXL1, MEF2A, CREBBP, RARA, ZNF35, ZNF384, NFYC, TAF15, SMAD4, CBFA2T3, RBM15, CDK8, SNRNP70, CSNK2A1, ZEB1, ZMYM3, NCOA1, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, TCF7, ZNF318, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, PKNOX1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, AHR, FOSL2, MBD3, DMAP1, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF274, NFIC, ZBTB5, CTCFL, PRDM1, KLF14, MECOM, HDAC3, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, ATRX, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, HINFP, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, USP7, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, TRPS1, HES1, TFE3, HBP1, EHF, IRF1, ZGPAT, MRTFB, ZC3H11A, ATF1, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF335, ZNF534, SMAD3, PCBP2, CBX8, TWIST1, PRPF4, NOTCH1, NCOA6, BRD9, RUNX2, CDK6, GATA4, ZSCAN30, GR, ZNF184, OSR2, PBX4, NRF1, SMAD2, FOS, CHD1, SUPT5H, MED1, KDM6B, CEBPD, SCRT2, MYB, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, PAX7, ZNF283, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, HIF1A, OTX2, ZNF519, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF837, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): ADARB1,TSPEAR,TRAPPC10,FAM207A
  • Function elements
  • Human SNPs: Body_mass_index
  • Number of somatic mutations (coding): 36
  • Number of somatic mutations (non-coding): 42
  • Related genes and loops
  • Related gene: ENSG00000160218, ENSG00000175894, ENSG00000160256, ENSG00000197381,
  • Related loop: chr21:43350000-43375000~~chr21:45075000-45100000, chr21:44075000-44100000~~chr21:45075000-45100000, chr21:44500000-44525000~~chr21:45050000-45075000, chr21:44948870-44950696~~chr21:45073682-45075829, chr21:44950000-44975000~~chr21:45075000-45100000, chr21:45050000-45075000~~chr21:45200000-45225000, chr21:45073104-45076272~~chr21:45127837-45129997, chr21:45075000-45100000~~chr21:45200000-45225000,
eachgene