- Basic information
- CohesinDB ID: CDBP00421170
- Locus: chr21-45078916-45079630
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Data sourse: GSE72082, ENCSR000BKV, GSE98367, GSE138405, ENCSR000HPG, ENCSR879KXD, GSE105028, GSE206145-NatGen2015, GSE206145, GSE120943, ENCSR000EDE, GSE68388, GSE103477, GSE126755, ENCSR000ECS
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Cell type: MCF-7, Macrophage, RPE, Hela-Kyoto, Fibroblast, Monocytes, HeLa-S3, IMR-90, K-562, Neutrophil, THP-1, HuCC-T1, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 36%,
"5_TxWk": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, HDGF, ATF3, RUNX3, ATF4, SMARCE1, MAF, JMJD1C, TEAD1, ETV1, LMO2, ESR1, USF2, JUN, CTCF, EP300, E4F1, LMO1, DPF2, SOX4, TEAD4, EED, POU2F2, ZSCAN5D, ZNF263, POU5F1, CDK7, TOP2A, MYCN, ZNF317, ZBTB17, STAT1, ZNF485, TBP, ERG, MYC, SMARCA4, RAD21, GABPA, STAT3, GFI1, IKZF1, RCOR1, NR3C1, CEBPB, STAT5B, KMT2A, CREB1, ZKSCAN5, ZHX2, SPI1, IRF1, HDAC2, GATA2, INTS13, FLI1, MXI1, SMARCA5, RUNX1, CBX1, BCL6, HDAC1, CEBPA, AFF4, ZFX, SMAD3, ERG3, NOTCH1, RUNX2, PBX4, ATF2, FOS, CDK8, SUPT5H, MED1, CEBPD, MYB, ZMYM3, SMAD1, GTF3C2, MAFK, SP1, BCL11A, RBM25, ATF7, ZHX1, POU2F3, PHIP, BCOR, SMC3, SKI, MEF2B, CBX3, CREM, ZNF600, ZNF692, MAFF, JDP2, MEF2C, CDK9, KDM1A, YY1, RELA, TARDBP, JUNB, ZFP36, OTX2, GATA3, TAL1, MAX, SPIB, ZNF143, GATA1, CEBPG, BCL11B, NR2F2, ZNF768, ZBTB6, NFKB1, BRD2, TBX21, BHLHE40, AR, ZBTB16, HSF1, BRD4, JUND, FOSL2
- Target gene symbol (double-evidenced CRMs): FAM207A,TRAPPC10,ADARB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 9
- Number of somatic mutations (non-coding): 3
- Related genes and loops
- Related gene:
ENSG00000160218,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:43350000-43375000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45075000-45100000,
chr21:44500000-44525000~~chr21:45050000-45075000,
chr21:44948870-44950696~~chr21:45073682-45075829,
chr21:44950000-44975000~~chr21:45075000-45100000,
chr21:45050000-45075000~~chr21:45200000-45225000,
chr21:45073104-45076272~~chr21:45127837-45129997,
chr21:45075000-45100000~~chr21:45200000-45225000,