- Basic information
- CohesinDB ID: CDBP00421171
- Locus: chr21-45080769-45082062
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Data sourse: ENCSR000EFJ, GSE67783, GSE86191, GSE138405, ENCSR000BLY, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX, GSE68388
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Cell type: Hela-Kyoto, Fibroblast, HCT-116, IMR-90, SK-N-SH, K-562, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 29%,
"7_Enh": 29%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOXO1, FOSL1, CEBPA, ZNF263, MYCN, SIN3A, ZFX, ZNF600, ZMYND11, ZSCAN16, ZBTB17, SMAD3, ID3, ERG3, ERG2, CDK9, MLL4, PBX2, KDM1A, RELA, JUNB, ATF3, RUNX2, SMARCA4, RAD21, PRDM1, PBX4, PROX1, NKX2-1, HMGB2, GATA3, TAL1, MAX, PBX3, FOS, IKZF1, CDK8, RCOR1, HAND2, ZNF639, ZNF467, CEBPB, SP7, MAF, STAT5B, TRIM28, MYB, SCRT2, KMT2A, TCF7L2, ETV1, TP53, TBX5, BRD2, TCF12, JUN, TBX21, AR, HDAC2, REST, POU2F3, FLI1, EED, SCRT1, BRD4, JUND, MXI1, TEAD4, TFAP2C, FOSL2
- Target gene symbol (double-evidenced CRMs): TRAPPC10,FAM207A,ADARB1
- Function elements
- Human SNPs: Smoking_initiation_(ever_regular_vs_never_regular)_(MTAG)
- Number of somatic mutations (coding): 12
- Number of somatic mutations (non-coding): 0
- Related genes and loops