- Basic information
- CohesinDB ID: CDBP00421179
- Locus: chr21-45096100-45096976
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Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE101921, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX
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Cell type: RPE, Fibroblast, HCT-116, HCAEC, RT-112, SK-N-SH, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 38%,
"15_Quies": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, MEIS2, XBP1, KDM4B, FOXA1, LEO1, PBX2, HDGF, ATF3, CTCFL, ZNF189, TP63, MITF, ELF1, TRIM28, ESR1, OCA2, PITX3, USF2, ZNF561, CTCF, JUN, ZNF577, EP300, GATA6, DPF2, RAD51, SMC1, FOXA3, GATAD2A, TFAP2C, EED, GLIS1, POU2F2, ZSCAN5D, MYCN, ZNF263, POU5F1, ID3, RUNX1T1, DUX4, ZBTB48, STAT1, ZSCAN5A, SRF, SAP130, ERG, ASCL1, ETS1, MYC, SMARCA4, ZNF2, RAD21, GRHL3, GABPA, ZNF8, XRCC5, IKZF1, RCOR1, DNMT3B, NR2F6, TERF2, KMT2A, CREB1, GRHL2, EBF3, SPI1, MIXL1, TFE3, GATA2, FLI1, MXI1, SMARCA5, RUNX1, THAP11, BCL6, SMC1A, LDB1, AFF4, ZFX, SMAD3, TET2, ZNF770, TRIM22, TWIST1, ZBTB2, ZNF35, ARNT, TFDP1, HMGB2, HMBOX1, ETV6, CHD1, SMARCB1, FOS, HMGXB4, MED1, TEAD3, ZNF558, CEBPD, SMAD1, C11orf30, TBX5, SREBF2, USF1, BCL11A, REST, POU2F3, PHIP, AATF, SMC3, STAG1, STAG2, TRP47, CBFA2T2, PPARG, MTA3, CREM, ZNF600, WT1, ZNF574, CDK9, YY1, RELA, TARDBP, NEUROD1, AHR, SP140, ZIC2, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, GATA1, ZNF143, HAND2, CBX2, CEBPG, NR2F2, NR2F1, NEUROG2, KDM5B, TP53, PKNOX1, ZNF334, PHOX2B, KAT8, TBX21, ARID4B, AR, RB1, HSF1, BRD4, JUND, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): ADARB1,FAM207A,TRAPPC10
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 9
- Number of somatic mutations (non-coding): 3
- Related genes and loops
- Related gene:
ENSG00000160218,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:43350000-43375000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45100000-45125000,
chr21:44950000-44975000~~chr21:45075000-45100000,
chr21:44950000-44975000~~chr21:45100000-45125000,
chr21:45000000-45025000~~chr21:45100000-45125000,
chr21:45075000-45100000~~chr21:45200000-45225000,
chr21:45098049-45099896~~chr21:45127459-45129775,
chr21:45098054-45099897~~chr21:45127466-45129726,
chr21:45098176-45099841~~chr21:45127847-45129707,
chr21:45098199-45099847~~chr21:45127871-45130307,
chr21:45098212-45099854~~chr21:45127500-45129746,
chr21:45098216-45099888~~chr21:45127480-45129775,
chr21:45098336-45099838~~chr21:45127832-45130027,
chr21:45098340-45099748~~chr21:45127945-45129475,
chr21:45098340-45099756~~chr21:45127809-45130230,
chr21:45098352-45099841~~chr21:45136497-45137989,
chr21:45098367-45099786~~chr21:45127883-45129461,
chr21:45098370-45099878~~chr21:45127837-45129997,
chr21:45098378-45099734~~chr21:45129555-45131317,
chr21:45098380-45099783~~chr21:45127879-45129458,
chr21:45100000-45125000~~chr21:45200000-45225000,
chr21:45101917-45103625~~chr21:45127837-45129997,
chr21:5100000-5125000~~chr21:45100000-45125000,