- Basic information
- CohesinDB ID: CDBP00421180
- Locus: chr21-45097465-45100018
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE126634, GSE25021, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, ENCSR000EDW, GSE108869, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE115250, GSE138405, GSE67783, GSE86191, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, GSE120943, GSE138105, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE93080, GSE94872, ENCSR000EEG, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, GSE97394, GSE55407, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS
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Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, HSPC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, TC-71, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 38% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.378
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 46%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, MEIS2, XBP1, KDM4B, FOXA1, LEO1, PBX2, HDGF, ATF3, CTCFL, ZNF189, TP63, MITF, ELF1, TRIM28, ESR1, OCA2, PITX3, USF2, ZNF561, CTCF, JUN, ZNF577, EP300, GATA6, DPF2, RAD51, SMC1, FOXA3, GATAD2A, TFAP2C, EED, GLIS1, POU2F2, ZSCAN5D, MYCN, ZNF263, POU5F1, ID3, RUNX1T1, DUX4, ZBTB48, STAT1, ZSCAN5A, SRF, SAP130, ERG, ASCL1, ETS1, MYC, SMARCA4, ZNF2, RAD21, GRHL3, GABPA, ZNF8, XRCC5, IKZF1, RCOR1, DNMT3B, NR2F6, TERF2, KMT2A, CREB1, GRHL2, EBF3, SPI1, MIXL1, TFE3, GATA2, FLI1, MXI1, SMARCA5, RUNX1, THAP11, BCL6, SMC1A, LDB1, AFF4, ZFX, SMAD3, TET2, ZNF770, TRIM22, TWIST1, ZBTB2, ZNF35, ARNT, TFDP1, HMGB2, HMBOX1, ETV6, CHD1, SMARCB1, FOS, HMGXB4, MED1, TEAD3, ZNF558, CEBPD, SMAD1, C11orf30, TBX5, SREBF2, USF1, BCL11A, REST, POU2F3, PHIP, AATF, SMC3, STAG1, STAG2, TRP47, CBFA2T2, PPARG, MTA3, CREM, ZNF600, WT1, ZNF574, CDK9, YY1, RELA, TARDBP, NEUROD1, AHR, SP140, ZIC2, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, GATA1, ZNF143, HAND2, CBX2, CEBPG, NR2F2, NR2F1, NEUROG2, KDM5B, TP53, PKNOX1, ZNF334, PHOX2B, KAT8, TBX21, ARID4B, AR, RB1, HSF1, BRD4, JUND, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): FAM207A,ADARB1,TRAPPC10
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 21
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000160218,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:43350000-43375000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45100000-45125000,
chr21:44950000-44975000~~chr21:45075000-45100000,
chr21:44950000-44975000~~chr21:45100000-45125000,
chr21:45000000-45025000~~chr21:45100000-45125000,
chr21:45075000-45100000~~chr21:45200000-45225000,
chr21:45098049-45099896~~chr21:45127459-45129775,
chr21:45098054-45099897~~chr21:45127466-45129726,
chr21:45098176-45099841~~chr21:45127847-45129707,
chr21:45098199-45099847~~chr21:45127871-45130307,
chr21:45098212-45099854~~chr21:45127500-45129746,
chr21:45098216-45099888~~chr21:45127480-45129775,
chr21:45098336-45099838~~chr21:45127832-45130027,
chr21:45098340-45099748~~chr21:45127945-45129475,
chr21:45098340-45099756~~chr21:45127809-45130230,
chr21:45098352-45099841~~chr21:45136497-45137989,
chr21:45098367-45099786~~chr21:45127883-45129461,
chr21:45098370-45099878~~chr21:45127837-45129997,
chr21:45098378-45099734~~chr21:45129555-45131317,
chr21:45098380-45099783~~chr21:45127879-45129458,
chr21:45100000-45125000~~chr21:45200000-45225000,
chr21:45101917-45103625~~chr21:45127837-45129997,
chr21:45102083-45103514~~chr21:45127466-45129726,
chr21:5100000-5125000~~chr21:45100000-45125000,