- Basic information
- CohesinDB ID: CDBP00421182
- Locus: chr21-45101929-45103660
-
Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE138405, GSE86191, GSE93080, GSE101921, GSE135093, GSE206145-NatGen2015, GSE138105, GSE130135, ENCSR703TNG, GSE94872, GSE98367, ENCSR193NSH, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE206145, ENCSR495WGO, ENCSR984DZW, GSE55407, ENCSR000BTQ, ENCSR853VWZ, ENCSR956LGB, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS
-
Cell type: MDM, RH4, GM10847, GM2610, SLK, GM19240, HSPC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, HFFc6, H1-hESC, SNYDER, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, GM19193, THP-1, GM19099, Macrophage, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 32% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.467
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 40%,
"7_Enh": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOSL1, SMARCA2, FOXA1, HDGF, NFIC, CTCFL, RUNX3, CBFB, TP63, ELF1, TEAD1, KLF6, ETV1, ESR1, HNF1B, TP73, OCA2, CTCF, JUN, TCF12, BAF155, EP300, KLF1, MNT, DPF2, SOX4, RFX5, E2F1, SMC1, TEAD4, TFAP2C, NANOG, CHD8, POU2F2, ZNF263, MYCN, ZBTB48, STAT1, SRF, HOXC5, ERG, ETS1, MYC, SMARCA4, RFX1, RAD21, GABPA, STAT3, XRCC5, UBN1, NKX3-1, NFE2, HNRNPH1, NR3C1, CEBPB, ZNF750, KMT2A, CREB1, SPI1, EHF, IRF1, HDAC2, GATA2, GATAD2B, FLI1, MRTFB, RUNX1, SMC1A, CBX1, ZFX, SMAD3, ZNF770, TRIM22, SMARCC1, CREBBP, ZBTB2, RUNX2, GATA4, ARNT, PBX4, PBX3, FOS, CDK8, MED1, ZEB1, PIAS1, KLF9, RBM22, SP1, REST, ZBTB7A, ZHX1, PHIP, TCF3, FOXP1, SMC3, STAG1, STAG2, PPARG, TBL1X, ZNF600, MAFF, WT1, CDK9, HOXB13, YY1, RELA, SP140, HIF1A, OTX2, GATA3, TAL1, MAX, MAF1, ZNF143, HAND2, TLE3, KLF4, KDM5B, TP53, PKNOX1, NFKB1, ELF3, AR, YAP1, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): FAM207A,TRAPPC10,ADARB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 21
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000160218,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:43350000-43375000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45100000-45125000,
chr21:44950000-44975000~~chr21:45075000-45100000,
chr21:44950000-44975000~~chr21:45100000-45125000,
chr21:45000000-45025000~~chr21:45100000-45125000,
chr21:45075000-45100000~~chr21:45200000-45225000,
chr21:45098049-45099896~~chr21:45127459-45129775,
chr21:45098054-45099897~~chr21:45127466-45129726,
chr21:45098176-45099841~~chr21:45127847-45129707,
chr21:45098199-45099847~~chr21:45127871-45130307,
chr21:45098212-45099854~~chr21:45127500-45129746,
chr21:45098216-45099888~~chr21:45127480-45129775,
chr21:45098336-45099838~~chr21:45127832-45130027,
chr21:45098340-45099748~~chr21:45127945-45129475,
chr21:45098340-45099756~~chr21:45127809-45130230,
chr21:45098352-45099841~~chr21:45136497-45137989,
chr21:45098367-45099786~~chr21:45127883-45129461,
chr21:45098370-45099878~~chr21:45127837-45129997,
chr21:45098378-45099734~~chr21:45129555-45131317,
chr21:45098380-45099783~~chr21:45127879-45129458,
chr21:45100000-45125000~~chr21:45200000-45225000,
chr21:45101917-45103625~~chr21:45127837-45129997,
chr21:45102083-45103514~~chr21:45127466-45129726,
chr21:5100000-5125000~~chr21:45100000-45125000,