- Basic information
- CohesinDB ID: CDBP00421183
- Locus: chr21-45103974-45105286
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Data sourse: GSE206145-GSE177045, GSE131606, ENCSR230ZWH, GSE67783, GSE72082, GSE138405, GSE86191, GSE206145, GSE101921, GSE62063, GSE206145-NatGen2015, ENCSR000EDE, ENCSR153HNT, ENCSR000EHX, GSE68388, GSE126990, ENCSR000ECS, ENCSR917QNE
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Cell type: MCF-7, RPE, Hela-Kyoto, Fibroblast, HCT-116, HCAEC, Ramos, HeLa-S3, SK-N-SH, K-562, Liver, HSPC, HuCC-T1, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.844
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 40%,
"7_Enh": 38%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, XBP1, FOXA1, LEO1, MLL4, ZFHX2, HDGF, NFIC, RUNX3, CHD7, MECOM, PAX5, SFPQ, ZNF629, KLF5, TEAD1, TRIM28, ZNF557, KLF6, ETV1, SNAI2, LMO2, ESR1, OCA2, ZNF561, CTCF, TCF12, SND1, BAF155, EP300, JUN, ZNF695, ZNF423, ZNF528, SMC1, KLF3, RBPJ, EED, TFAP2C, GLIS1, POU2F2, CHD8, NANOG, MYCN, BRD3, TOP2A, RUNX1T1, CTBP1, MTA2, ZMYND11, ZNF317, ZBTB48, STAT1, ZBTB17, ERF, NBN, ERG2, HNF4G, ERG, ZNF597, NFKB2, ETS1, MYC, ZBTB8A, SMARCA4, ZNF2, ZNF341, GRHL3, RXRA, GABPA, STAT3, SOX10, NKX3-1, IKZF1, NR3C1, KMT2A, CREB1, EZH2, FEZF1, GRHL2, EBF3, SPI1, IRF1, ZNF257, HDAC2, GATA2, ZNF182, GATAD2B, FLI1, HCFC1, RELB, NCOA2, RUNX1, BCL6, EZH2phosphoT487, NKX2-2, CRY1, AFF4, ZFX, ZNF335, SMAD3, ZNF770, ERG3, TRIM22, ZNF18, PRDM10, SMARCC1, CREBBP, ZNF35, ZNF384, RUNX2, OSR2, ARNT, DAXX, PBX4, ATF2, PBX3, FOXM1, ETV6, FOS, ZNF10, MED1, ZXDB, MYB, ZNF680, PIAS1, SCRT2, ZMYM3, ZNF3, EVI1, TBX5, ZNF22, RBM22, BCL11A, NIPBL, SP1, REST, ARID1A, ASH2L, PHIP, TCF3, FOXP1, BCOR, PRDM6, ZNF337, SMC3, ZNF34, STAG1, MLLT1, MEF2B, FOXA2, EBF1, CREM, PAF1, SS18, ZNF600, ZNF692, ZSCAN16, WT1, FOXF1, ZNF574, MEF2C, TCF7, HOXB13, BCL3, YY1, RELA, TARDBP, NEUROD1, AHR, BRG1, ZNF610, SP140, ZIC2, HIF1A, ZFP36, TCF4, OTX2, GATA3, BATF, TAL1, MAX, SPIB, NRIP1, HAND2, TLE3, TCF7L2, NR2F1, TP53, PKNOX1, NFKB1, EGR2, ELF3, ZNF843, BRD2, ARRB1, TBX21, BHLHE40, AR, EGLN2, ZBTB42, IKZF2, BRD4, SCRT1, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): ADARB1,FAM207A,TRAPPC10
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 9
- Number of somatic mutations (non-coding): 3
- Related genes and loops
- Related gene:
ENSG00000160218,
ENSG00000160256,
ENSG00000197381,
- Related loop:
chr21:43350000-43375000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45075000-45100000,
chr21:44075000-44100000~~chr21:45100000-45125000,
chr21:44950000-44975000~~chr21:45075000-45100000,
chr21:44950000-44975000~~chr21:45100000-45125000,
chr21:45000000-45025000~~chr21:45100000-45125000,
chr21:45075000-45100000~~chr21:45200000-45225000,
chr21:45098049-45099896~~chr21:45127459-45129775,
chr21:45098054-45099897~~chr21:45127466-45129726,
chr21:45098176-45099841~~chr21:45127847-45129707,
chr21:45098199-45099847~~chr21:45127871-45130307,
chr21:45098212-45099854~~chr21:45127500-45129746,
chr21:45098216-45099888~~chr21:45127480-45129775,
chr21:45098336-45099838~~chr21:45127832-45130027,
chr21:45098340-45099748~~chr21:45127945-45129475,
chr21:45098340-45099756~~chr21:45127809-45130230,
chr21:45098352-45099841~~chr21:45136497-45137989,
chr21:45098367-45099786~~chr21:45127883-45129461,
chr21:45098370-45099878~~chr21:45127837-45129997,
chr21:45098378-45099734~~chr21:45129555-45131317,
chr21:45098380-45099783~~chr21:45127879-45129458,
chr21:45100000-45125000~~chr21:45200000-45225000,
chr21:45101917-45103625~~chr21:45127837-45129997,
chr21:45102083-45103514~~chr21:45127466-45129726,
chr21:5100000-5125000~~chr21:45100000-45125000,