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Basic information

CohesinDB ID: CDBP00421191

Locus: chr21-45124436-45132048

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 84% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.100

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 33%, "7_Enh": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, PAX5, TEAD1, ZNF121, LMO2, OCA2, PITX3, ZNF561, E4F1, SOX5, DEK, ZNF528, KMT2B, GATAD2A, ZNF263, POU5F1, TOP2A, ERF, ZMYND11, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, CRY1, TET2, ZNF654, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ATF2, SMARCB1, PIAS1, SMAD1, C11orf30, IKZF5, ELL2, NFATC3, CBFA2T2, MEF2B, ZNF207, CREM, CHD2, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, TCF4, BATF, KLF4, ZFP69B, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, SCRT1, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, PBX2, ATF3, ZC3H8, THRB, ZFP64, RUNX3, CBFB, ZSCAN4, MITF, ZNF467, JMJD1C, MAF, ELF1, SNAI2, KLF10, CTCF, JUN, LMO1, ZBTB20, MNT, DPF2, IRF4, ZNF280A, PDX1, RBPJ, MLX, TFAP2C, MTA2, ZBTB17, ZBTB48, ZNF317, SRF, DDX5, NBN, ZNF2, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, KMT2A, KLF8, EBF3, SMARCA5, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZNF18, ARNT, DAXX, ZNF48, ZEB2, HMBOX1, PBX3, MAFB, ZNF10, HMGXB4, TEAD3, KLF9, TBX5, USF1, BCL11A, TFAP2A, SP1, NKX2-5, ZNF479, ATF7, ASH2L, PRDM6, SMC3, STAG1, MLLT1, STAG2, TRP47, AGO1, EBF1, MAFF, ZNF580, KDM1A, BRG1, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, CBX2, TP53, ZNF334, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, IKZF2, BRD4, JUND, TBX2, PGR, SOX2, PATZ1, LEO1, UBTF, TFAP4, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, KLF1, SOX4, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, ARID1B, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, SPI1, HDAC2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, ZNF35, ZNF384, RARA, NFYC, SMAD4, ZNF518A, CBFA2T3, CDK8, ZEB1, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, TBL1X, ZNF692, ZNF574, ZNF823, TCF7, RELA, TARDBP, SKIL, MAX, NR2F1, KDM5B, PKNOX1, MYOD1, T, ZNF12, AR, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, ZFHX2, NFIC, CTCFL, PRDM1, GLYR1, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, RCOR2, USF2, TCF12, BAF155, EP300, E2F1, SMC1, TEAD4, FOXA3, EED, CHD8, BRD1, MYCN, CDK7, ID3, GATAD1, ARID3A, USP7, ASCL1, ZNF341, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ZNF639, JMJD6, FEZF1, TFE3, IRF1, SREBF1, ZGPAT, ZNF284, MRTFB, MAFG, SMC1A, CBX1, ZNF335, ZFX, SMAD3, TWIST1, NOTCH1, RUNX2, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF3, PHIP, TCF3, PAX7, SKI, FOXA2, E2F8, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, BHLHE22, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, NFKBIZ, ZNF579, ZBTB42, MYNN, MAZ

Target gene symbol (double-evidenced CRMs): PTTG1IP,TRPM2,PCBP3,COL6A2,FAM207A,ADARB1,ITGB2-AS1,COL18A1,SLC19A1,CFAP410,PFKL,DNMT3L,TSPEAR,SUMO3,TRAPPC10,UBE2G2,POFUT2,ITGB2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 111

Number of somatic mutations (non-coding): 31

Related genes and loops

Related gene: ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421191