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Basic information

CohesinDB ID: CDBP00421192

Locus: chr21-45132786-45143934

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 84% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.122

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 40%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, ZNF660, ZSCAN5C, SOX2, NME2, XBP1, PATZ1, FOXA1, LEO1, PBX2, RXRB, ZFHX2, KDM3A, HDGF, ATF3, NFIC, HNRNPUL1, THAP1, RUNX3, ZNF444, ATF4, MORC2, MXD4, ZNF189, SMARCE1, PAX5, ZSCAN4, CDX2, JMJD1C, ZNF629, KLF5, ELF1, TRIM28, BCLAF1, RBM39, TEAD1, NFE2L2, KLF10, ZNF217, ESR1, ETV1, OCA2, PITX3, USF2, ZNF561, ZNF524, CTCF, TCF12, JUN, BAF155, EP300, MNT, SOX5, DPF2, E2F6, IRF4, RFX5, E2F4, ZXDC, ZNF410, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GATAD2A, PDX1, TFAP2C, EED, RBPJ, GLIS1, POU2F2, CHD8, NANOG, ZNF263, POU5F1, MYCN, ID3, RUNX1T1, CTBP1, ZMYND11, ZBTB17, ZBTB48, STAT1, NONO, SRF, GATAD1, SAP130, NBN, MLLT3, ERG2, TBP, ERG, HOXC5, ASCL1, ETS1, MYC, EZH1, SMARCA4, RFX1, ZNF2, RAD21, HOMEZ, FOXP2, EOMES, RXRA, NKX2-1, FOXK2, PROX1, GABPA, STAT3, XRCC5, ZNF614, NKX3-1, MIER3, HNRNPH1, ZNF639, NR2F6, VDR, RCOR1, NR3C1, CEBPB, SRSF3, DNMT3B, CREB1, EZH2, KLF8, JMJD6, GRHL2, EBF3, ZHX2, SPI1, TFE3, MIXL1, HBP1, KLF17, HDAC2, GATA2, SSRP1, MXD3, SREBF1, FLI1, DRAP1, MXI1, ZGPAT, SMARCA5, MRTFB, NFIL3, ZNF554, ZIM3, ATF1, ETV5, CC2D1A, RUNX1, THAP11, CIITA, SMC1A, CBX1, CEBPA, NKX2-2, HDAC1, BCL6, SIN3A, ZFX, AFF4, FIP1L1, SOX13, SMAD3, POU4F2, REPIN1, ZNF654, ZNF770, ERG3, TRIM22, SMARCC1, PRDM10, ZNF18, TWIST1, ZBTB2, CREBBP, PRPF4, NOTCH1, ZNF35, RARA, ZNF384, ZSCAN30, GATA4, OSR2, NFE2, ARNT, BACH1, TFDP1, NRF1, ZNF48, ZEB2, NFYA, SMAD4, FOS, HMGXB4, SMARCB1, CDK8, CHD1, MED1, TEAD3, TERF1, MYB, PIAS1, U2AF1, SMAD1, ZNF3, NCOA1, L3MBTL2, EVI1, MBD1, RBM22, USF1, NIPBL, BCL11A, TFAP2A, SP1, HNF4A, MAFK, FOXA2, ARID2, REST, IKZF5, MAF, ATF7, ZHX1, ASH2L, HNRNPLL, TCF3, BCOR, FOXP1, SMC3, ELL2, ZNF34, STAG2, STAG1, MLLT1, ZNF394, SKI, LDB1, TBL1X, MTA3, EBF1, CREM, CHD2, ZNF207, ZNF600, ZNF692, MIER2, WT1, ZSCAN16, ZNF574, MEF2C, CDK9, ZNF580, ZKSCAN1, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, ZNF610, ZFP36, HIF1A, SKIL, TCF4, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, GATA1, CEBPG, BCL11B, SP7, GFI1B, TCF7L2, NEUROG2, KDM5B, TP53, PKNOX1, ZNF213, ZSCAN22, MYOD1, EGR2, BRD2, ELF3, KAT8, PHF5A, TBX21, NFKBIZ, ARID4B, BHLHE40, AR, ZNF579, ZBTB40, TAF1, ZNF324, YAP1, EGLN2, ZBTB42, EGR1, RB1, ZBTB26, HSF1, MYNN, BRD4, ILF3, JUND, SCRT1, MAZ, ZNF24, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): SLC19A1,COL6A2,PCBP3,ITGB2,TRAPPC10,PTTG1IP,COL18A1,PFKL,DNMT3L,ADARB1,TSPEAR,ITGB2-AS1,TRPM2,POFUT2,CFAP410,UBE2G2,FAM207A,SUMO3

Function elements

Human SNPs: Serum_platinum_levels_after_completion_of_cisplatin_chemotherapy

Number of somatic mutations (coding): 364

Number of somatic mutations (non-coding): 54

Related genes and loops

Related gene: ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421192