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Basic information

CohesinDB ID: CDBP00421195

Locus: chr21-45147401-45149408

Data sourse: GSE67783, GSE86191, ENCSR000EHW, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, ENCSR000EHX, ENCSR703TNG

Cell type: MCF-7, RPE, Fibroblast, HCT-116, SK-N-SH, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SMC3,Rad21,SA2,SA1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 50%, "15_Quies": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, CBFA2T2, BCL6, ZNF283, FOXA2, MYCN, TOP2A, ZFX, ZNF600, ZMYND11, ZBTB17, ZBTB48, ZSCAN5A, STAT1, WT1, ESR2, TET2, ERG3, LEO1, ERG2, ZFHX2, ERG, YY1, RELA, CREBBP, OGG1, ATF3, MYC, SMARCA4, ZFP64, SP140, GRHL3, TAL1, CBFA2T3, MAX, STAT3, GATA1, AGO2, RCOR1, CHD1, DNMT3B, MED1, ZNF143, ZNF750, ZFP69B, KLF5, ELF1, TFAP2C, NR2F1, ESR1, PITX3, GRHL2, ZNF334, EBF3, EGR2, CTCF, JUN, RBM22, BCL11A, EP300, BHLHE40, AR, GATA2, ZBTB7A, RXR, EGR1, HSF1, MXI1, BRD4, SCRT1, TCF3, MAZ, AATF, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): COL18A1,ITGB2,ITGB2-AS1,TRAPPC10,COL6A2,TRPM2,PFKL,DNMT3L,PTTG1IP,TSPEAR,FAM207A,CFAP410,SLC19A1,UBE2G2,ADARB1,PCBP3,POFUT2,SUMO3

Function elements

Human SNPs: Adult_body_size

Number of somatic mutations (coding): 56

Number of somatic mutations (non-coding): 14

Related genes and loops

Related gene: ENSG00000160218, ENSG00000142182, ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421195