Browse_each

Basic information

CohesinDB ID: CDBP00421198

Locus: chr21-45151534-45152963

Data sourse: ENCSR000BLD, ENCSR230ZWH, ENCSR000FAD, GSE72082, GSE126634, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, GSE25021, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE115250, GSE67783, GSE86191, GSE101921, GSE135093, GSE152721, GSE120943, ENCSR198ZYJ, GSE206145-NatGen2015, GSE130135, GSE116344, GSE106870, GSE145327, GSE94872, GSE115248, GSE98367, GSE168045, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE62063, ENCSR000BMY, ENCSR000EHX, GSE97394, GSE55407, GSE38411, GSE155324, ENCSR153HNT, GSE83726, GSE50893, GSE126755, GSE131577

Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, B-cell, H9-hESC, GM2630, Fibroblast, THP-1, Kelly, GM12890, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Ramos, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, SC, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 31% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.367

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 36%, "7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF675, SOX2, MEIS2, XBP1, KDM4B, FOXA1, SUZ12, RBFOX2, LEO1, PBX2, UBTF, ZFHX2, TFAP4, SIN3B, HDGF, ATF3, THAP1, CTCFL, CHD7, WDHD1, PRDM1, ZNF444, RUNX3, CBFB, ZNF189, SMARCE1, PAX5, MITF, CDX2, JMJD1C, INTS11, MAF, ELF1, TEAD1, TRIM28, RBM39, BCLAF1, NFE2L2, ETV1, ZNF217, ESR1, OCA2, SAP30, LMO2, HDAC8, USF2, CTCF, JUN, TCF12, BAF155, KLF1, E4F1, MNT, EP300, ARID5B, LMO1, DPF2, RYBP, E2F6, TRIM24, SOX6, E2F4, ZNF674, RAD51, SMC1, TEAD4, KMT2B, GTF2F1, EHMT2, TFAP2C, PDX1, EED, GLIS1, RBPJ, GATAD2A, POU2F2, CHD8, NANOG, MYCN, ZNF263, CDK7, ID3, RUNX1T1, CTBP1, MTA2, POU5F1, ZBTB48, ZSCAN5A, STAT1, SRF, NBN, ERG2, TBP, ERG, PBX1, OGG1, ETS1, MYC, EZH1, SMARCA4, ARID1B, RAD21, FOXP2, GRHL3, PROX1, NKX2-1, FOXK2, GABPA, XRCC5, IKZF1, RCOR1, DNMT3B, DACH1, NFE2, VDR, NR3C1, ESRRA, CEBPB, ZNF93, KMT2A, CREB1, EZH2, GRHL2, GABPB1, PHF8, ELF4, ZHX2, SPI1, HDAC2, GATA2, INTS13, GATAD2B, FLI1, HCFC1, SMARCA5, RELB, HCFC1R1, EP400, NCOA2, ATF1, PTBP1, RUNX1, CBX1, BCL6, HDAC1, SMC1A, CEBPA, SIN3A, ZFX, ZNF534, AFF4, SMAD3, NMYC, ERG3, TRIM22, ZMIZ1, ZNF18, SMARCC1, NSD2, TWIST1, CREBBP, ZBTB2, NOTCH1, RARA, ARNT, NRF1, BACH1, TFDP1, SNIP1, HMBOX1, ZEB2, NFYA, CBFA2T3, PBX3, ETV6, FOS, CDK8, SNRNP70, SMAD4, MED1, GMEB1, TEAD3, DIDO1, CEBPD, MYB, TERF1, ZEB1, SMAD1, SUPT16H, ZNF3, ZMYM3, NCOA1, L3MBTL2, EVI1, SETDB1, STAT5A, KLF16, RBM22, USF1, BCL11A, MAFK, SP1, PHF20, REST, ZBTB7A, RBM25, ATF7, HNRNPLL, TCF3, BCOR, FOXP1, AATF, ZNF623, SMC3, STAG1, MLLT1, NFATC3, SKI, AGO1, CBFA2T2, KLF13, FOXA2, ZNF207, MTA3, MEIS1, CBX3, CREM, ZNF600, RBBP5, TBL1X, WT1, MAFF, EBF1, MEF2C, ZBTB33, TCF7, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, NEUROD1, AHR, KAT2B, SP140, TCF4, SKIL, ZFP36, GATA3, BATF, MGA, TAL1, MAX, NRIP1, GATA1, MTA1, ZNF143, SPIB, HAND2, AGO2, CBX2, PLAG1, KLF4, BCL11B, ZNF592, NCOA3, NR2F2, GFI1B, NR2F1, KDM5B, TP53, PKNOX1, MED, MYOD1, EGR2, TBX21, BHLHE40, AR, TAF1, ZNF579, ZBTB40, EGLN2, EGR1, RB1, ZBTB26, NCOR1, RNF2, BRD4, ILF3, JUND, CLOCK, HSF1, MAZ, MYNN, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): POFUT2,ADARB1,COL18A1,PCBP3

Function elements

Human SNPs: HDL_cholesterol_levels

Number of somatic mutations (coding): 48

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421198