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Basic information

CohesinDB ID: CDBP00421200

Locus: chr21-45154600-45155466

Data sourse: ENCSR000BLD, ENCSR000EFJ, GSE86191, ENCSR000BLY, ENCSR000EHW, GSE206145-NatGen2015, GSE206145, ENCSR000EHX, ENCSR153HNT, GSE25021, GSE165895

Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, IMR-90, SK-N-SH, K-562, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 42%, "7_Enh": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, ZNF496, ZSCAN5C, SOX2, ZNF621, FOXA1, SUZ12, LEO1, PBX2, ZFHX2, HDGF, NFIC, CHD7, ZNF322, ZNF444, TP63, MITF, ZNF467, CDC5L, BCLAF1, ESR1, PITX3, USF2, CTCF, TCF12, EP300, KLF1, E4F1, MNT, GLI4, ZNF423, ZNF512B, ZNF776, TEAD4, PDX1, TFAP2C, RBPJ, EHMT2, GLIS1, YBX1, POU2F2, CHD8, MYCN, ZNF239, ZNF263, ID3, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, ZSCAN5A, NONO, SRF, ZBTB1, DDX5, ERG2, ZNF300, ERG, PBX1, MYC, RFX1, TSHZ1, FOXP2, RAD21, GABPA, ZNF8, NKX3-1, ZNF398, RCOR1, HNRNPH1, NR3C1, ESRRA, CREB1, KLF8, ARHGAP35, GRHL2, EBF3, HES1, ZNF202, HDAC2, GATA2, SSRP1, GATAD2B, ZNF146, MXI1, ZNF785, MRTFB, HDAC1, NKX2-2, LDB1, ZNF707, ZFX, POU4F2, SMAD3, ZNF473, ERG3, TET2, TWIST1, ZNF549, NOTCH1, RUNX2, SMAD2, OSR2, ARNT, NFIB, ELK1, ATF2, SMAD4, CBFA2T3, SP2, MED1, CEBPD, MYB, ZNF680, RBM22, USF1, MAFK, BCL11A, PHF20, REST, ZBTB7A, HNRNPLL, PHIP, SALL1, FOXP1, TCF3, SMC3, STAG1, FOXA2, CBX3, MTA3, CHD2, ZNF207, ZNF600, WT1, ZNF662, KDM1A, YY1, RELA, TARDBP, NEUROD1, ZNF521, ZNF282, SP140, TCF4, HIF1A, ZIC2, ZFP36, ZNF311, TAL1, MAX, GATA1, ZNF143, HAND2, KLF4, ZNF592, NCOA3, ZNF544, NEUROG2, ZNF791, NR2F1, TP53, PKNOX1, ZNF687, ZSCAN22, NFKB1, EGR2, BHLHE40, AR, PAX3-FOXO1, TAF1, RXR, ZFP41, ZBTB42, ZNF366, EGR1, ZBTB26, BRD4, MAZ, ZSCAN23, AHR

Target gene symbol (double-evidenced CRMs): POFUT2,ADARB1,COL18A1,PCBP3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 8

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421200