- Basic information
- CohesinDB ID: CDBP00421205
- Locus: chr21-45163388-45165275
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Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE83726
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Cell type: RPE, Fibroblast, RH4, HCT-116, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
85% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 47%,
"15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, TRIM25, PGR, ZSCAN5C, XBP1, FOXA1, LEO1, ZFHX2, ATF3, NFIC, PAX5, TP63, MITF, MYOG, ELF1, TRIM28, SNAI2, ESR1, OCA2, USF2, CTCF, TCF12, BAF155, MNT, PAX8, TRIM24, E2F1, TEAD4, GLIS1, POU2F2, BRD1, MYCN, POU5F1, ZNF263, MTA2, DUX4, ZBTB48, ZSCAN5A, ERG2, ERG, PBX1, ASCL1, OGG1, MYC, SMARCA4, GRHL3, STAT3, XRCC5, NKX3-1, PRDM14, DNMT3B, NR3C1, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, SPI1, GATA2, SIX2, FLI1, MYF5, RUNX1, BCL6, SIRT6, CRY1, SIN3A, ZFX, ZNF534, TET2, ERG3, TAF15, RUNX2, CHD1, ZNF264, SCRT2, PIAS1, ZNF680, ZNF3, TBX5, SREBF2, RBM22, USF1, NKX2-5, REST, ATF7, HOXA9, HNRNPLL, TCF3, BCOR, AATF, SMC3, NCOR2, STAG1, TRP47, MEF2B, FOXA2, EBF1, PAF1, ZNF600, WT1, HOXB13, YY1, RELA, TARDBP, JUNB, NEUROD1, SP140, ZFP36, TCF4, ZIC2, OTX2, MAF1, MAX, TAL1, AGO2, CBX2, TLE3, NEUROG2, NR2F1, KDM5B, TP53, PKNOX1, ZNF334, NFKB1, MYOD1, EGR2, TBX21, AR, EGR1, HEXIM1, HSF1, SCRT1, BRD4, MAZ
- Target gene symbol (double-evidenced CRMs): PCBP3,POFUT2,ADARB1,COL18A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 36
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000197381,
ENSG00000186866,
ENSG00000182871,
ENSG00000183570,
- Related loop:
chr21:45150000-45175000~~chr21:45250000-45275000,
chr21:45150000-45175000~~chr21:45275000-45300000,
chr21:45150000-45175000~~chr21:45425000-45450000,
chr21:45150000-45175000~~chr21:45450000-45475000,
chr21:45150000-45175000~~chr21:45725000-45750000,
chr21:45150000-45175000~~chr21:45800000-45825000,