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Basic information

CohesinDB ID: CDBP00421222

Locus: chr21-45201822-45203368

Data sourse: GSE67783, GSE86191, GSE116868, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE131606, GSE165895

Cell type: RPE, Fibroblast, HCT-116, MB157, DKO, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 53%, "4_Tx": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, TRIM25, CHD8, MYCN, POU5F1, KDM4C, ZFX, ZBTB48, WT1, ESR2, ZSCAN5A, TET2, ERG3, LEO1, TWIST1, PRDM10, YY1, RELA, CREBBP, OGG1, ATF3, EZH1, MYC, SP140, GRHL3, HIF1A, ARNT, NRF1, MAX, TP63, NRIP1, AGO2, DNMT3B, HAND2, KDM6B, CREB1, NR2F1, ESR1, ZNF334, MYOD1, EBF3, PHOX2B, CTCF, RBM22, AR, HSF1, BRD4, JUND, MAZ, AATF, SMC3, STAG1, AHR

Target gene symbol (double-evidenced CRMs): TSPEAR,TRPM2,ADARB1,FAM207A,COL6A2,PCBP3,COL18A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 80

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000142185, ENSG00000175894, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000183570, ENSG00000142173,

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Deatailed information for cohesin site CDBP00421222