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Basic information

CohesinDB ID: CDBP00421224

Locus: chr21-45206724-45207526

Data sourse: ENCSR000BLD, ENCSR000BTQ, GSE72082, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR000ECE, ENCSR153HNT, GSE68388, ENCSR703TNG, GSE25021

Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, K-562, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 55%, "4_Tx": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, GLIS1, CHD8, SMC1A, MYCN, ZNF263, TOP2A, ZFX, MAFF, ZBTB48, STAT1, WT1, SMAD3, TET2, NMYC, PBX2, ZNF384, AHR, MYC, ZNF362, RAD21, ARNT, GATA3, MAX, TP63, GATA1, HAND2, TRIM28, TFAP2C, NR2F1, PKNOX1, C11orf30, GRHL2, SETDB1, PHOX2B, CTCF, MAFK, TFAP2A, GATA6, GATA2, ZBTB7A, RBM25, MAZ, ZNF440, TEAD4, TBX2, STAG1, ZNF316, EED

Target gene symbol (double-evidenced CRMs): COL18A1,ADARB1,PCBP3,TSPEAR,FAM207A,COL6A2,TRPM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 30

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000142185, ENSG00000175894, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000183570, ENSG00000142173,

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Deatailed information for cohesin site CDBP00421224