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Basic information

CohesinDB ID: CDBP00421228

Locus: chr21-45211669-45211971

Data sourse: ENCSR000FAD, GSE98367, ENCSR000BLY, ENCSR000EHW, ENCSR153HNT, ENCSR000EHX, GSE73207

Cell type: K-562, TF-1, Macrophage, SK-N-SH

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SMC3,Rad21,SA1,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 47%, "4_Tx": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, TRIM25, NME2, MEIS2, XBP1, FOXA1, PBX2, HDGF, ATF3, NFIC, ZNF362, RUNX3, PRDM1, ATF4, MORC2, CBFB, SMARCE1, PAX5, ZSCAN4, MITF, MAF, ZNF629, JMJD1C, ELF1, BCLAF1, TRIM28, TEAD1, ESR1, MLL, PITX3, USF2, CTCF, JUN, SND1, TCF12, EP300, ZBTB20, DPF2, IRF4, GLI4, RAD51, ZNF512B, E2F1, TEAD4, RBPJ, EED, POU2F2, CHD8, MYCN, POU5F1, RUNX1T1, ZNF263, ID3, TOP2A, MTA2, ZSCAN21, ZBTB48, ZSCAN5A, STAT1, ZBTB17, KDM4C, SRF, DDX5, NBN, ERG, ASCL1, MYC, SMARCA4, ARID1B, RAD21, GRHL3, RXRA, PROX1, FOXK2, BATF3, STAT3, PRDM14, IKZF1, RCOR1, HNRNPH1, NR2F6, VDR, NR3C1, CEBPB, KMT2A, CREB1, EZH2, KLF8, FEZF1, EBF3, SPI1, IRF1, GATA2, GATAD2B, MXD3, FLI1, DRAP1, SMARCA5, RELB, NCOA2, ATF1, RUNX1, BCL6, SMC1A, CEBPA, HDAC1, ZFX, SMAD3, TET2, ERG3, TRIM22, SMARCC1, MEF2A, ZBTB2, ZNF384, ZNF35, ZNF169, RUNX2, CDK6, ARNT, NFIB, PBX4, ZBTB10, BACH1, ZNF48, ATF2, HMBOX1, ETV6, PBX3, FOXM1, FOS, CDK8, MED1, ZEB1, TERF1, MYB, SCRT2, RBM22, USF1, NIPBL, BCL11A, REST, ZBTB7A, ATF7, BCOR, PRDM6, SMC3, NCOR2, MLLT1, STAG1, ZNF394, NFATC3, SKI, TRP47, CBFA2T2, MEF2B, PPARG, MTA3, EBF1, CREM, CHD2, ZNF600, WT1, ZNF662, MEF2C, CDK9, HOXB13, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, JUNB, ISL1, SP140, HIF1A, SKIL, GATA3, BATF, TAL1, MAX, SPIB, ZNF143, GATA1, HAND2, ZNF592, NCOA3, NR2F1, TP53, PKNOX1, ZNF687, ZNF334, MYOD1, PHOX2B, BRD2, TBX21, BHLHE40, PAX3-FOXO1, AR, ZBTB40, RXR, ZNF324, EGR1, HSF1, NCOR1, IKZF2, BRD4, NOTCH3, JUND, CLOCK, RNF2, MAZ, ILF3, ZSCAN23, TBX2, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): TRPM2,FAM207A,COL18A1,COL6A2,TSPEAR,ADARB1,PCBP3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 5

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000142185, ENSG00000175894, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421228