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Basic information

CohesinDB ID: CDBP00421233

Locus: chr21-45225776-45226165

Data sourse: ENCSR000BKV, GSE86191, GSE25021, ENCSR000BLY, ENCSR153HNT, ENCSR000EHX, GSE83726, GSE131606, GSE38411

Cell type: MCF-7, HCT-116, RH4, K-562, SK-N-SH, BCBL-1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 85% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "5_TxWk": 40%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, TRIM25, PGR, SOX2, XBP1, FOXA1, SUZ12, LEO1, PBX2, MLL4, TFAP4, ATF3, BMI1, NFIC, CTCFL, CHD7, PRDM1, RUNX3, ATF4, CBFB, DPF1, ZNF189, TP63, MITF, ZNF736, JMJD1C, MAF, ELF1, TEAD1, ETV1, SNAI2, NFE2L2, RBM39, ESR1, OCA2, TP73, MED26, USF2, JUN, CTCF, TCF12, BAF155, E4F1, EP300, MNT, SOX4, E2F6, RAD51, E2F1, TEAD4, TFAP2C, EED, RBPJ, GLIS1, NANOG, CHD8, BRD1, MYCN, ZNF263, RUNX1T1, POU5F1, CDK7, ID3, ZMYND11, TOP2A, ZBTB48, ZSCAN5A, SRF, ERG2, HNF4G, ERG, ZNF300, HOXC5, ASCL1, OGG1, MYC, SMARCA4, FOXP2, RAD21, GRHL3, PROX1, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, PRDM14, RCOR1, DNMT3B, HNRNPH1, VDR, NR3C1, CEBPB, KMT2A, CREB1, CCAR2, EZH2, BMPR1A, GRHL2, EBF3, ZHX2, SPI1, HDAC2, GATA2, SSRP1, FLI1, RELB, MRTFB, ZNF554, MYF5, PTBP1, RUNX1, CIITA, SMC1A, BCL6, CEBPA, SIRT6, EZH2phosphoT487, CRY1, SIN3A, ZFX, SMAD3, TET2, CBX8, ERG3, SMARCC1, TWIST1, RARA, RUNX2, CDK6, GATA4, ARNT, PBX4, ZBTB10, PBX3, NCAPH2, CHD1, CDK8, FOS, MED1, TEAD3, KDM6B, MYB, SCRT2, PIAS1, SUPT16H, ZNF3, KLF9, L3MBTL2, SETDB1, RBM22, USF1, BCL11A, MAFK, NIPBL, HNF4A, TFAP2A, REST, ARID1A, ASH2L, PHIP, MBD2, FOXP1, AATF, ZNF623, SMC3, STAG1, NFATC3, TRP47, FOXA2, MTA3, CREM, PAF1, NFATC1, ZNF600, SS18, WT1, ZBTB33, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, ZNF19, JUNB, AHR, BRG1, MCM3, SP140, ZFP36, HIF1A, OTX2, GATA3, BATF, MGA, TAL1, MAX, MAF1, NRIP1, ZNF143, AGO2, SPIB, GATA1, PLAG1, CBX2, CEBPG, TLE3, NCOA3, NR2F1, TCF7L2, KDM5B, TP53, MYOD1, EGR2, BRD2, TBX21, BHLHE40, AR, TAF1, RXR, HEXIM1, TFIIIC, HSF1, RNF2, ZBTB26, JUND, BRD4, SCRT1, CLOCK, MAZ, ZNF24, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): ADARB1

Function elements

Human SNPs: Type_2_diabetes

Number of somatic mutations (coding): 10

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000197381,

eachgene

Deatailed information for cohesin site CDBP00421233