Deatailed information for cohesin site CDBP00421247

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  • Basic information
  • CohesinDB ID: CDBP00421247
  • Locus: chr21-45251073-45259845
  • Data sourse: ENCSR000BLD, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, GSE105028, GSE121355, GSE73207, GSE131606, GSE25021, ENCSR000EFJ, ENCSR000BTU, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE116344, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS, GSE38411
  • Cell type: RH4, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, BCBL-1, DKO, H1-hESC, Monocytes, MB157, TF-1, SK-N-SH, RT-112, Macrophage, MCF-7, GM12892, HCT-116, Hep-G2, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 14% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.744
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TES,Intragenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "14_ReprPCWk": 21%, "13_ReprPC": 19%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, THAP1, MORC2, PAX5, LMO2, OCA2, PITX3, HDAC8, ZNF507, E4F1, SOX5, PAX8, DEK, E2F4, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, CTBP1, STAT1, SAP130, ERG, SMARCA4, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, NR2C2, DRAP1, RELB, RUNX1, CEBPA, HDAC1, TET2, SP5, ZBTB2, FOXM1, SMARCB1, PML, SMAD1, EVI1, STAT5A, ARID2, IKZF5, AFF1, MBD2, CBFA2T2, CBX3, CREM, CHD2, PAF1, WT1, CREB3L1, JUNB, NEUROD1, TCF4, ZFP36, PLAG1, BCL11B, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, XBP1, HNF1A, KDM4B, PBX2, ATF3, ZFP64, CBFB, DPF1, TP63, MITF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, MNT, LMO1, ZBTB20, DPF2, RYBP, IRF4, ZNF567, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, NONO, NBN, PHB2, CHD4, PBX1, ZNF329, PRDM14, LEF1, HNRNPH1, TEAD2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, GRHL2, EBF3, SMARCA5, CC2D1A, THAP11, LDB1, SOX13, ZMIZ1, ARNT, NFIB, ZNF48, ZEB2, NFYA, NCAPH2, HMGXB4, TEAD3, KLF9, ZNF41, USF1, SP1, BCL11A, NKX2-5, ATF7, ASH2L, GLIS2, SMC3, STAT2, STAG1, MLLT1, TRP47, AGO1, MTA3, EBF1, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, ZNF143, MTA1, AGO2, CBX2, TP53, ZNF334, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, TBX2, PGR, SOX2, UBTF, TFAP4, CHD7, MXD4, ZNF189, SMARCE1, RLF, KLF6, NFE2L2, ESR1, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZBTB1, ZSCAN5A, ERG2, OGG1, SMARCC2, ETS1, MYC, ARID1B, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, NFYB, ETV5, BCL6, SIN3A, ERG3, CREBBP, RARA, ZNF384, TAF15, SMAD4, CBFA2T3, CDK8, NCOA1, NR4A1, REST, HNRNPLL, BCOR, AATF, TCF7, FOXO3, RELA, TARDBP, ZNF282, SKIL, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, ZBTB16, YAP1, HEXIM1, ZNF395, AHR, FOSL2, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, LYL1, ZNF90, ZNF274, NFIC, CTCFL, MECOM, HDAC3, KLF5, TRIM28, ETV1, HNF1B, USF2, TCF12, EP300, SOX6, RAD51, ZNF512B, E2F1, TEAD4, ZNF175, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ASCL1, ZNF341, MCM5, RAD21, GRHL3, APC, XRCC5, NFE2, ZNF639, ZNF750, HES1, TFE3, SREBF1, MRTFB, ZIM3, ZC3H11A, ATF1, PTBP1, SMC1A, SIRT6, ZFX, SMAD3, PCBP2, CBX8, TWIST1, IRF2, RUNX2, NRF1, FOS, CHD1, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, ZBTB7A, CCNT2, TCF3, NCOA4, FOXA2, RBBP5, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, BHLHE22, GATA1, HAND2, CEBPG, NCOA3, NR2F2, ZNF512, ZNF687, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): TRAPPC10,POFUT2,ADARB1,ITGB2-AS1,ITGB2,FAM207A
  • Function elements
  • Human SNPs: Logical_memory_(immediate_recall)_in_mild_cognitive_impairment
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 20
  • Related genes and loops
  • Related gene: ENSG00000160218, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866,
  • Related loop: chr21:27500000-27525000~~chr21:45225000-45250000, chr21:44075000-44100000~~chr21:45250000-45275000, chr21:44925000-44950000~~chr21:45250000-45275000, chr21:44950000-44975000~~chr21:45250000-45275000, chr21:45125000-45150000~~chr21:45225000-45250000, chr21:45125000-45150000~~chr21:45250000-45275000, chr21:45139756-45141227~~chr21:45256456-45257780, chr21:45150000-45175000~~chr21:45250000-45275000, chr21:45225000-45250000~~chr21:45325000-45350000,
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