- Basic information
- CohesinDB ID: CDBP00421248
- Locus: chr21-45261057-45263926
-
Data sourse: ENCSR000BTU, ENCSR230ZWH, GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR635OSG, ENCSR153HNT, ENCSR917QNE
-
Cell type: RPE, Fibroblast, HCT-116, Ishikawa, RT-112, K-562, Liver, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"5_TxWk": 46%,
"4_Tx": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOSL1, PGR, XBP1, FOXA1, RBFOX2, LEO1, ZFHX2, ATF3, ELF1, ESR1, CTCF, BAF155, TFAP2C, POU2F2, ZSCAN5D, MYCN, ZNF263, TOP2A, ZBTB48, ERG2, HNF4G, ERG, ETS1, MYC, RAD21, RXRA, GABPA, STAT3, NKX3-1, PRDM14, DNMT3B, CEBPB, CREB1, SPI1, GATA2, NCOA2, ETV5, SMC1A, CEBPA, ZFX, TET2, CBX8, ERG3, TAF15, ARNT, ZNF48, FOS, SUPT5H, SCRT2, PIAS1, RBM22, SP1, HNF4A, ARID2, REST, STAG1, MLLT1, ZNF394, TRP47, FOXA2, MEIS1, PAF1, ZNF600, WT1, ZBTB33, HOXB13, YY1, RELA, SP140, TCF4, HIF1A, TAL1, MAX, NRIP1, GATA1, AGO2, PLAG1, NR2F1, ZNF334, NFKB1, EGR2, AR, HEXIM1, HSF1, ZBTB26, MYNN, BRD4, SCRT1, ILF3, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): ADARB1,POFUT2,TRAPPC10,ITGB2,ITGB2-AS1,FAM207A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000160218,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
ENSG00000186866,
- Related loop:
chr21:44075000-44100000~~chr21:45250000-45275000,
chr21:44925000-44950000~~chr21:45250000-45275000,
chr21:44950000-44975000~~chr21:45250000-45275000,
chr21:45125000-45150000~~chr21:45250000-45275000,
chr21:45139756-45141227~~chr21:45256456-45257780,
chr21:45150000-45175000~~chr21:45250000-45275000,