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Basic information

CohesinDB ID: CDBP00421249

Locus: chr21-45264207-45270973

Data sourse: ENCSR000BLD, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE93080, GSE67783, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, SLK, CVB-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, K-562, BCBL-1, H1-hESC, MB157, GM12878, SK-N-SH, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HUVEC, HCAEC, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 21% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.689

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "4_Tx": 48%, "5_TxWk": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, XBP1, FOXA1, RBFOX2, LEO1, ATF3, RUNX3, CBFB, MECOM, TP63, MAF, ELF1, TEAD1, TRIM28, SNAI2, LMO2, ESR1, CTCF, JUN, TCF12, LMO1, TFAP2C, EED, CHD8, ZNF263, MYCN, CDK7, KDM4C, POU5F1, ZBTB48, STAT1, ERG, PBX1, OGG1, MYC, SMARCA4, GRHL3, GABPA, STAT3, APC, PRDM14, IKZF1, RCOR1, DNMT3B, NR3C1, ESRRA, STAT5B, KMT2A, KLF8, BMPR1A, ZHX2, FLI1, PTBP1, RUNX1, CEBPA, ZFX, RARA, RUNX2, SUPT5H, CHD1, FOS, MED1, TEAD3, TERF1, KDM6B, MYB, ZNF3, RBM22, BCL11A, REST, RBM25, HNRNPLL, TCF3, AATF, SMC3, HMGB1, STAG1, TRP47, FOXA2, TBL1X, E2F8, WT1, ZBTB33, CDK9, YY1, RELA, SP140, TCF4, GATA3, BATF, TAL1, MAF1, ZNF143, AGO2, BCL11B, NR2F1, KDM5B, TP53, MYOD1, TBX21, AR, ZNF445, RXR, HEXIM1, TFIIIC, HSF1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): FTCD,TRAPPC10,ADARB1,POFUT2,FAM207A,ITGB2,ITGB2-AS1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 956

Number of somatic mutations (non-coding): 239

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000160282,

eachgene

Deatailed information for cohesin site CDBP00421249