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Basic information

CohesinDB ID: CDBP00421251

Locus: chr21-45278276-45280924

Data sourse: GSE67783, GSE86191, GSE25021, GSE206145-NatGen2015, ENCSR153HNT, GSE131606

Cell type: MCF-7, Fibroblast, HCT-116, K-562, HSPC, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "4_Tx": 78%, "5_TxWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, FOSL1, SOX2, XBP1, ZNF101, SUZ12, RBFOX2, LEO1, HDGF, ZNF90, ATF3, THAP1, CBFB, MECOM, TP63, ZNF467, CDX2, MYOG, ELF1, RBM39, LMO2, ESR1, OCA2, TP73, HDAC8, CTCF, JUN, TCF12, ZNF157, DPF2, E2F4, RAD51, TEAD4, RBPJ, EED, TFAP2C, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, RUNX1T1, TOP2A, POU5F1, ZBTB48, ZSCAN5A, STAT1, DDX5, ERG2, TBP, ERG, PBX1, ASCL1, OGG1, ETS1, MYC, SMARCA4, ARID1B, RAD21, FOXP2, GRHL3, STAT3, XRCC5, IKZF1, DNMT3B, HNRNPH1, NR3C1, CEBPB, HNRNPL, CREB1, EZH2, GRHL2, GABPB1, ZHX2, IRF1, GATA2, MXD3, FLI1, HCFC1R1, MYF5, ETV5, RUNX1, BCL6, SMC1A, HDAC1, LDB1, CEBPA, SIN3A, ZFX, TET2, ERG3, ZNF384, TAF15, CDK6, ZNF48, PRDM9, CBFA2T3, NCAPH2, FOS, CDK8, SUPT5H, SNRNP70, CHD1, TEAD3, ZEB1, KDM6B, ZNF558, ZNF3, SREBF2, RBM22, USF1, ARID2, REST, HNRNPLL, TCF3, GLIS2, AATF, SMC3, STAG1, TRP47, CBFA2T2, ZNF283, AGO1, FOXA2, PAF1, ZNF600, WT1, ZNF662, ZBTB33, YY1, RELA, TARDBP, SP140, ZIC2, HIF1A, TCF4, TAL1, MAX, ZNF143, AGO2, PLAG1, CEBPG, NR2F1, NEUROG2, KDM5B, TP53, ZNF334, MYOD1, EGR2, BHLHE40, AR, ZNF445, RXR, HEXIM1, EGR1, TFIIIC, HSF1, ZBTB26, BRD4, JUND, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ITGB2-AS1,ITGB2,TRAPPC10,PCBP3,COL18A1,ADARB1,FAM207A,POFUT2,SLC19A1

Function elements

Human SNPs: Coronary_artery_calcified_atherosclerotic_plaque_(90_or_130_HU_threshold)_in_type_2_diabetes

Number of somatic mutations (coding): 45

Number of somatic mutations (non-coding): 15

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421251