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Basic information

CohesinDB ID: CDBP00421254

Locus: chr21-45286477-45297005

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 87% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.089

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 28%, "7_Enh": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, SFPQ, TEAD1, LMO2, OCA2, MED26, ZNF561, E4F1, ARID5B, ZNF75A, SOX5, E2F4, DEK, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, ERF, STAT1, SAP130, ERG, ZBTB21, EZH1, SMARCA4, RFX1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, MXD3, FLI1, HCFC1, MXI1, NR2C2, DRAP1, RELB, EP400, RUNX1, HDAC1, NKX2-2, CEBPA, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ELK1, ATF2, SP2, SMARCB1, PML, SMAD1, C11orf30, MBD1, ARID2, IKZF5, MBD2, ELL2, ETV4, NFATC3, MEF2B, CREM, CHD2, NFATC1, SS18, WT1, CREB3L1, NEUROD1, JUNB, ZFP36, PLAG1, KLF4, BCL11B, ZNF281, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, HSF1, ZBTB26, NCOR1, ILF3, FOSL1, XBP1, KDM4B, PBX2, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, ZNF467, MAF, INTS11, JMJD1C, ELF1, RBM39, KLF10, SMAD5, FUS, CTCF, TAF3, JUN, LMO1, MNT, RYBP, DPF2, SIX5, IRF4, PDX1, TFAP2C, MLX, RBPJ, ZBTB17, ZBTB48, NONO, SRF, NBN, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, SP3, ARNT, DAXX, BACH1, NFIB, ZNF48, NFYA, NCAPH2, ZNF10, HMGXB4, TEAD3, ZXDB, TAF7, KLF9, USF1, BCL11A, TFAP2A, SP1, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, KLF7, ZKSCAN1, KDM1A, BRG1, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, TP53, ZSCAN22, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, TBX2, ZNF468, PGR, PATZ1, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, KLF1, ZNF695, E2F6, TRIM24, RFX5, U2AF2, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, EZH2, PHF8, SPI1, ZNF202, PCBP1, HDAC2, RBP2, INTS13, ZNF76, NFYB, ETV5, BCL6, SIN3A, ERG3, RARA, CREBBP, NFYC, ZNF384, TAF15, ZNF518A, SMAD4, CDK8, ZEB1, SREBF2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, YY2, FOXO3, RELA, TARDBP, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, AR, HEXIM1, DMAP1, AHR, FOSL2, MBD3, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, CTCFL, KLF14, MECOM, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, E2F1, SMC1, TEAD4, FOXA3, ZNF175, CHD8, BRD1, MYCN, RUNX1T1, CDK7, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, ZNF45A, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, IRF2, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, NRF1, NR2C1, CHD1, SUPT5H, FOS, MED1, KDM6B, CEBPD, MYB, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, SP140, HIF1A, OTX2, ZNF519, GATA1, CEBPG, SP7, NR2F2, NFKBIZ, BHLHE40, TAF1, ZBTB40, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): PCBP3,SLC19A1,ITGB2,POFUT2,COL18A1,ITGB2-AS1,TRAPPC10,ADARB1,FAM207A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 72

Number of somatic mutations (non-coding): 129

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421254