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Basic information

CohesinDB ID: CDBP00421255

Locus: chr21-45297393-45298845

Data sourse: ENCSR167MTG, GSE72082, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, ENCSR917QNE

Cell type: K-562, Liver, Fibroblast, Hep-G2

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 52%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, ZBTB44, IKZF3, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, HDAC8, ZNF561, E4F1, SOX5, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, TOP2A, CTBP1, STAT1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, HCFC1, MXI1, RUNX1, CEBPA, NKX2-2, ZNF654, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ATF2, FOXM1, SP2, PML, PIAS1, SMAD1, C11orf30, EVI1, MBD1, IKZF5, ARID2, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, ZFP36, BATF, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, ZNF530, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, PBX2, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, CBFB, TP63, MITF, ZNF467, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, MNT, ZBTB20, RYBP, DPF2, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZNF317, ZBTB17, ZBTB48, NONO, SRF, ZNF2, HOMEZ, FOXP2, RXRA, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, SSRP1, NFIL3, CC2D1A, THAP11, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZMIZ1, ZNF18, ARNT, BACH1, NFIB, DAXX, ZNF48, PRDM9, ZEB2, ETV6, NCAPH2, ZNF10, MAFB, HMGXB4, PBX3, TEAD3, ZXDB, KLF9, USF1, SP1, BCL11A, ATF7, ASH2L, GLIS2, ZNF623, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, MTA3, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, ZNF768, TP53, ZNF334, ZSCAN22, PHF5A, BRD2, KAT8, ARRB1, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, PGR, CBX5, PATZ1, LEO1, UBTF, SMAD1-5, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, MZF1, RLF, KLF6, NFE2L2, ZNF217, ESR1, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZSCAN5A, ERG2, SP4, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, ZNF343, DNMT3B, INO80, SRSF3, EZH2, ZNF652, SPI1, PCBP1, HDAC2, GATAD2B, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, RARA, NFYC, CREBBP, ZNF384, TAF15, ZNF35, HMGB2, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, RELA, TARDBP, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, ZBTB16, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, HMGN3, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, COBLL1, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ID3, MLLT3, GATAD1, ARID3A, USP7, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, JMJD6, TFE3, EHF, SREBF1, ZGPAT, MRTFB, ZC3H11A, MYF5, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, FIP1L1, ZNF534, ZFX, ZNF335, SMAD3, NMYC, CBX8, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, ZNF184, OSR2, NRF1, PBX4, NR2C1, FOS, CHD1, MED1, KDM6B, MYB, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, ZNF600, MIER2, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF610, SP140, HIF1A, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF846, ZBTB40, ZBTB42, MYNN, MAZ, ZNF440, ZNF24

Target gene symbol (double-evidenced CRMs): PCBP3,ITGB2,COL18A1,TRAPPC10,ITGB2-AS1,ADARB1,SLC19A1,FAM207A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421255