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Basic information

CohesinDB ID: CDBP00421256

Locus: chr21-45299162-45312040

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 66% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.278

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 34%, "5_TxWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, THAP1, ZNF322, IKZF3, TEAD1, LMO2, OCA2, MED26, HDAC8, E4F1, SOX5, PAX8, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, ZNF263, BRD3, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, EZH1, SMARCA4, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, MXI1, RUVBL2, RUNX1, ZMYM2, HDAC1, CEBPA, CRY1, TET2, SP5, TRIM22, SMARCC1, ZBTB2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, SMAD1, MBD1, STAT5A, ARID2, IKZF5, ZNF605, AFF1, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, MCM3, ZFP36, TCF4, MAF1, PLAG1, ZFP69B, KLF4, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, HNF1A, XBP1, KDM4B, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, CBFB, TP63, ZSCAN4, MITF, MAF, JMJD1C, MYOG, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, L3MBTL4, MNT, LMO1, DPF2, RYBP, IRF4, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZBTB17, ZBTB48, NONO, SRF, NBN, CHD4, PBX1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, GRHL2, SSRP1, NFIL3, CC2D1A, THAP11, SOX13, AFF4, POU4F2, ZNF770, ARNT, BACH1, ZNF48, PRDM9, HMBOX1, NFYA, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, U2AF1, KLF9, TBX5, USF1, SP1, BCL11A, NKX2-5, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, TRP47, AGO1, MTA3, EBF1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF266, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, TP53, SMAD1-5-8, ZNF334, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, IRF9, SMAD4.1D12, PGR, SOX2, PATZ1, UBTF, SMAD1-5, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, HNF4G, OGG1, SMARCC2, ETS1, MYC, ARID1B, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, NFYC, ZNF35, TAF15, CBFA2T3, CDK8, ZEB1, ZNF264, ZMYM3, SREBF2, RBM22, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, ZNF662, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, ZBTB16, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, NFIC, CTCFL, PRDM1, ZNF629, KLF5, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, HES1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, TWIST1, IRF2, PRPF4, RUNX2, GATA4, ZNF184, NRF1, ZNF708, NR2C1, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, YY1, SP140, HIF1A, GATA1, HAND2, CEBPG, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, ZBTB40, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): TRAPPC10,SLC19A1,COL18A1,FAM207A,POFUT2,ITGB2-AS1,ITGB2,ADARB1,PCBP3

Function elements

Human SNPs: Core_binding_factor_acute_myeloid_leukemia

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 95

Related genes and loops

Related gene: ENSG00000160218, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421256