Deatailed information for cohesin site CDBP00421257

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  • Basic information
  • CohesinDB ID: CDBP00421257
  • Locus: chr21-45312982-45313691
  • Data sourse: GSE206145, GSE67783, ENCSR153HNT, GSE86191
  • Cell type: K-562, HCT-116, HSPC, RPE
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.956
  • Subunit: SA1,Rad21
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 43%, "14_ReprPCWk": 19%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, THAP1, ZNF322, IKZF3, TEAD1, LMO2, OCA2, MED26, HDAC8, E4F1, SOX5, PAX8, E2F4, DEK, ZNF528, KMT2B, GATAD2A, JARID2, ZNF263, BRD3, TOP2A, CTBP1, DUX4, STAT1, SAP130, ERG, EZH1, SMARCA4, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, MXI1, RUVBL2, RUNX1, ZMYM2, HDAC1, CEBPA, CRY1, TET2, SP5, TRIM22, SMARCC1, ZBTB2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, SMAD1, MBD1, STAT5A, ARID2, IKZF5, ZNF605, AFF1, ELL2, ETV4, NFATC3, CBFA2T2, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, MCM3, ZFP36, TCF4, MAF1, PLAG1, ZFP69B, KLF4, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, NCOR1, ZBTB26, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, HNF1A, XBP1, KDM4B, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, CBFB, TP63, ZSCAN4, MITF, MAF, JMJD1C, MYOG, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, L3MBTL4, MNT, LMO1, DPF2, RYBP, IRF4, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZBTB17, ZBTB48, NONO, SRF, NBN, CHD4, PBX1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, GRHL2, SSRP1, NFIL3, CC2D1A, THAP11, SOX13, AFF4, POU4F2, ZNF770, ARNT, BACH1, ZNF48, PRDM9, HMBOX1, NFYA, ZEB2, PBX3, NCAPH2, HMGXB4, TEAD3, U2AF1, KLF9, TBX5, USF1, SP1, BCL11A, NKX2-5, ZNF479, ATF7, ASH2L, GLIS2, SMC3, STAG1, MLLT1, STAG2, TRP47, AGO1, MTA3, EBF1, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF266, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, TP53, SMAD1-5-8, ZNF334, NFKB1, ZSCAN22, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, IRF9, SMAD4.1D12, PGR, SOX2, PATZ1, UBTF, SMAD1-5, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, TBP, HNF4G, OGG1, SMARCC2, ETS1, MYC, ARID1B, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF384, NFYC, ZNF35, TAF15, CBFA2T3, CDK8, ZEB1, ZNF264, ZMYM3, SREBF2, RBM22, MAFK, HNF4A, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, ZNF662, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, AR, ZBTB16, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, NFIC, CTCFL, PRDM1, ZNF629, KLF5, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, HES1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, TWIST1, IRF2, PRPF4, RUNX2, GATA4, ZNF184, NRF1, ZNF708, NR2C1, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, CDK9, YY1, SP140, HIF1A, GATA1, HAND2, CEBPG, NCOA3, NR2F2, BHLHE40, NFKBIZ, TAF1, ZBTB40, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): COL18A1,PCBP3,ADARB1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 3
  • Related genes and loops
  • Related gene: ENSG00000197381, ENSG00000182871, ENSG00000183570,
  • Related loop: chr21:45125000-45150000~~chr21:45300000-45325000, chr21:45139737-45141278~~chr21:45308098-45309917, chr21:45139742-45141196~~chr21:45308481-45309869, chr21:45139772-45141201~~chr21:45308090-45309979, chr21:45139849-45141273~~chr21:45308581-45309918, chr21:45151182-45153539~~chr21:45307919-45309932, chr21:45151733-45153242~~chr21:45308637-45309801, chr21:45291650-45293537~~chr21:45307909-45309938, chr21:45291652-45295569~~chr21:45307925-45310422, chr21:45291678-45293713~~chr21:45308127-45310479, chr21:45300000-45325000~~chr21:45400000-45425000, chr21:45300000-45325000~~chr21:45425000-45450000, chr21:45300000-45325000~~chr21:45450000-45475000, chr21:45300000-45325000~~chr21:45800000-45825000, chr21:45300000-45325000~~chr21:46050000-46075000, chr21:45301558-45303184~~chr21:45316995-45320847, chr21:45308127-45310479~~chr21:45366272-45368100, chr21:45316984-45320873~~chr21:45363408-45365405, chr21:45316995-45320847~~chr21:45363412-45365343, chr21:45316995-45320847~~chr21:45366272-45368100,
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