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Basic information

CohesinDB ID: CDBP00421258

Locus: chr21-45316533-45338135

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR000BUC, ENCSR000DYE, ENCSR000EFJ, ENCSR000BTU, ENCSR917QNE, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE138105, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, ENCSR000ECS, ENCSR481YWD, GSE38411

Cell type: RH4, SLK, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, HeLa-S3, IMR-90, BCBL-1, K-562, HFFc6, DKO, H1-hESC, Monocytes, MB157, SK-N-SH, RT-112, HeLa-Tet-On, THP-1, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 45% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.644

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 32%, "5_TxWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, IKZF3, PAX5, TEAD1, ZNF121, LMO2, OCA2, HDAC8, ZNF561, E4F1, ZNF157, SOX5, PYGO2, PAX8, E2F4, DEK, ZNF410, ZNF528, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, BRD3, TOP2A, CTBP1, ERF, ZMYND11, STAT1, ZNF488, ZNF563, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, FOXK2, ZNF8, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, HCFC1, MXI1, ZNF785, HCFC1R1, RUNX1, HDAC1, CEBPA, NKX2-2, ZNF707, REPIN1, TET2, ZNF473, TBX3, SP5, MCM2, TRIM22, SMARCC1, PRDM10, ZXDC, ZBTB2, ELK1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PML, TERF1, ZNF331, PIAS1, NR1H2, MBD1, STAT5A, ARID2, IKZF5, RBM25, MBD2, ELL2, ETV4, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, BATF, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZNF544, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, FOSL1, SMARCA2, ZNF660, ZNF621, XBP1, HNF1A, KDM4B, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, TP63, ZSCAN4, MITF, CDC5L, ZNF467, MAF, JMJD1C, ELF1, RBM39, SNAI2, ZNF624, CTCF, JUN, MNT, ZBTB20, DPF2, RYBP, SIX5, IRF4, MED12, ZNF423, ZNF776, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, PLRG1, YBX1, MTA2, ZBTB17, ZBTB48, ZNF317, ZSCAN21, NONO, SRF, DDX5, NBN, PBX1, ONECUT1, TSHZ1, HOMEZ, FOXP2, ZNF2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, KLF8, ARHGAP35, GRHL2, ZNF565, EBF3, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, LDB1, SOX13, AFF4, ZNF747, ZFP3, ZNF770, ZNF18, NFIB, ARNT, DAXX, ZNF48, PRDM9, ZEB2, PBX3, MAFB, ZNF10, HMGXB4, TEAD3, ZXDB, ZNF670, ZNF680, U2AF1, KLF9, TBX5, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, ZNF548, CTBP2, GLIS2, SMC3, STAG1, STAG2, MLLT1, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, ZNF266, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF645, ZNF334, ZSCAN22, BRD2, PHF5A, KAT8, ZFP41, EGR1, RNF2, BRD4, JUND, CUX1, ZSCAN23, ZNF468, PGR, SOX2, PATZ1, UBTF, SMAD1-5, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, MCM7, NFE2L2, ZNF217, ESR1, TP73, ZNF524, KLF1, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, ZSCAN5D, ZBTB1, ZSCAN5A, ELK4, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, PHF8, ZNF436, SPI1, PCBP1, HDAC2, GATAD2B, ATM, ZNF490, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, RARA, ZNF384, NFYC, TAF15, ZNF35, ZNF280C, SMAD4, CDK8, ZEB1, ZMYM3, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, PPARG, TBL1X, ZNF692, ZNF30, ZNF574, ZNF662, TCF7, RELA, TARDBP, ZNF282, MAX, ZNF592, GFI1B, BAP1, TCF7L2, NR2F1, KDM5B, ZNF791, NEUROG2, PKNOX1, MYOD1, AR, PAX3-FOXO1, YAP1, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, LCORL, ZSCAN5C, E2F7, HMGN3, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF90, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, ZNF736, HDAC3, CDX2, ZNF629, ZNF506, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, HNF1B, USF2, TCF12, EP300, BAF155, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, MLLT3, GATAD1, ARID3A, ASCL1, ZNF341, MCM5, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF667, ZNF639, ZNF750, FEZF1, TRPS1, HES1, TFE3, ZNF664, HBP1, IRF1, ZSCAN2, SREBF1, ZGPAT, MRTFB, MYF5, PTBP1, CBX1, SMC1A, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, PCBP2, CBX8, TWIST1, PRPF4, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, NRF1, NR2C1, CHD1, FOS, MED1, CEBPD, KDM6B, SCRT2, MYB, ZNF558, ZNF3, L3MBTL2, SETDB1, NIPBL, PHF20, ZBTB7A, POU2F3, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, MIER2, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF521, SP140, HIF1A, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, MYNN, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): FAM207A,COL18A1,LSS,SLC19A1,COL6A2,PCBP3,TRPM2,CFAP410,TSPEAR,ADARB1,MCM3AP-AS1,PFKL,PTTG1IP,UBE2G2,SUMO3

Function elements

Human SNPs: Systemic_lupus_erythematosus

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 137

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173, ENSG00000160285, ENSG00000215424,

eachgene

Deatailed information for cohesin site CDBP00421258