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Basic information

CohesinDB ID: CDBP00421262

Locus: chr21-45342847-45354233

Data sourse: ENCSR000BLD, GSE104888, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE131606, GSE108869, GSE25021, ENCSR917QNE, GSE165895, GSE67783, GSE86191, GSE76893, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, ENCSR703TNG, GSE145327, GSE94872, GSE118494, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR000BTQ, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE83726, GSE126755, ENCSR000ECS, GSE131577

Cell type: RH4, Liver, H9-hESC, RPE, Fibroblast, HeLa-S3, IMR-90, K-562, DKO, HFFc6, H1-hESC, Monocytes, MB157, SK-N-SH, RT-112, Macrophage, HUES64, MCF-7, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, HUVEC, Neutrophil, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 16% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.711

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 25%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, TRIM25, HMG20A, ZNF660, SOX2, XBP1, FOXA1, SUZ12, RXRB, MLL4, ATF3, NFIC, ZBTB44, CHD7, PRDM1, MORC2, MXD4, PAX5, TP63, ZNF736, ELF1, TEAD1, TRIM28, ETV1, RCOR2, ESR1, LMO2, OCA2, ZNF561, CTCF, JUN, TCF12, EP300, MNT, SOX5, E2F6, RFX5, E2F4, TEAD4, FOXA3, GATAD2A, RBPJ, TFAP2C, GLIS1, POU2F2, CHD8, ZNF263, MYCN, ZNF317, ZBTB48, ZSCAN5A, STAT1, GATAD1, SAP130, ERG, OGG1, ZBTB8A, ETS1, MYC, MCM5, SMARCA4, EZH1, HOMEZ, RAD21, GRHL3, PROX1, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, IKZF1, DNMT3B, NR2F6, NR3C1, CEBPB, CREB1, EZH2, FEZF1, GABPB1, MIXL1, TFE3, EHF, MXD3, FLI1, DRAP1, ZGPAT, MRTFB, NFIL3, ETV5, RUNX1, THAP11, BCL6, CEBPA, SOX13, ZFX, ZNF534, FIP1L1, TET2, SP5, SMARCC1, PRDM10, CREBBP, ZNF35, ZNF384, CDK6, ARNT, PBX4, ZNF48, SMAD4, FOXM1, FOS, HMGXB4, TEAD3, CEBPD, SCRT2, ZNF331, SETDB1, USF1, BCL11A, ARID2, REST, ZBTB7A, IKZF5, ASH2L, PHIP, FOXP1, PRDM6, AATF, ZNF337, SMC3, NCOR2, STAG1, NFATC3, TRP47, PPARG, FOXA2, MIER2, ZNF600, ZSCAN16, WT1, ZBTB33, CDK9, ZNF580, KDM1A, YY1, RELA, JUNB, AHR, BRG1, MCM3, SP140, ZIC2, HIF1A, MAX, ZNF143, PLAG1, CEBPG, NCOA3, NR2F1, TP53, NFKB1, PHOX2B, ELF3, KAT8, ARID4B, AR, RXR, EGLN2, EGR1, HEXIM1, HSF1, ZBTB26, NCOR1, BRD4, MAZ, DMAP1

Target gene symbol (double-evidenced CRMs): COL18A1,UBE2G2,SLC19A1,PTTG1IP,PFKL,CFAP410,TRPM2,SUMO3,PCBP3,LSS,COL6A2,TSPEAR,FAM207A,ADARB1,MCM3AP-AS1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 88

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000183255, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173, ENSG00000160285, ENSG00000215424,

eachgene

Deatailed information for cohesin site CDBP00421262