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Basic information

CohesinDB ID: CDBP00421273

Locus: chr21-45401908-45445613

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, GSE168045, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE80989, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE73207, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, TF-1, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, SC, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, VU1199-F, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 88% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.089

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,ESCO2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 24%, "5_TxWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, HDGF, PAX5, TEAD1, LMO2, HDAC8, SOX5, DEK, ZNF528, RFX3, GATAD2A, NANOG, ZNF263, BRD3, POU5F1, CTBP1, STAT1, ZNF134, SAP130, ERG, ZBTB21, SMARCA4, FOXK2, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RUVBL2, RUNX1, CEBPA, HDAC1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, ZXDC, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, NR1H2, MBD1, IKZF5, ARID2, RBM25, MBD2, ELL2, ETV4, CBFA2T2, ZNF207, CREM, CHD2, SS18, PAF1, WT1, JUNB, NEUROD1, ZFP36, PLAG1, KLF4, EGR2, ELF3, ARID4B, RXR, HSF1, ZBTB26, ILF3, FOSL1, ZNF660, XBP1, HNF1A, KDM4B, PBX2, TSC22D4, ATF3, THRB, ZFP64, WDHD1, TP63, MITF, ZNF467, ELF1, RBM39, SNAI2, KLF10, CTCF, JUN, MNT, RYBP, DPF2, PDX1, RBPJ, TFAP2C, MLX, MTA2, ZSCAN21, ZBTB48, NONO, SRF, CHD4, HOMEZ, FOXP2, RXRA, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, TBL1XR1, KLF8, GRHL2, ZNF146, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, SOX13, AFF4, ARNT, DAXX, NFIB, ZNF48, ZEB2, HMBOX1, PBX3, ZNF10, HMGXB4, TEAD3, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, AGO1, MTA3, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, BRD2, PHF5A, KAT8, EGR1, RNF2, BRD4, JUND, CUX1, SMAD4.1D12, PGR, PATZ1, SMAD1-5, UBTF, TFAP4, SIN3B, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, ZSCAN5D, ZSCAN5A, ERG2, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, ZNF436, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, CREBBP, RARA, NFYC, ZNF384, TAF15, CBFA2T3, CDK8, ZEB1, ZMYM3, SUPT16H, NCOA1, GTF3C2, RBM22, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, ZNF692, TCF7, FOXO3, RELA, TARDBP, MAX, NR2F1, TCF7L2, KDM5B, MYOD1, AR, YAP1, HEXIM1, DMAP1, AHR, FOSL2, MBD3, HMG20A, LCORL, RBFOX2, ZFHX2, INSM2, NFIC, KLF14, ZNF629, ETV1, RCOR2, HNF1B, USF2, TCF12, EP300, BAF155, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, BRD1, MYCN, SRC, ID3, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, ZNF639, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZNF534, ZFX, SMAD3, TWIST1, PRPF4, RUNX2, CDK6, ZNF184, NRF1, PBX4, FOS, CHD1, TGIF2, MED1, CEBPD, KDM6B, VEZF1, ZNF3, L3MBTL2, NIPBL, ZBTB7A, PHIP, SKI, KLF13, FOXA2, RBBP5, ZNF600, MIER2, ZBTB33, YY1, SP140, HIF1A, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, MYNN, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): PCBP3,COL18A1,FAM207A,AGPAT3,ITGB2,POFUT2,ADARB1,TSPEAR,ITGB2-AS1

Function elements

Human SNPs: Brain_morphology_(MOSTest)

Number of somatic mutations (coding): 406

Number of somatic mutations (non-coding): 170

Related genes and loops

Related gene: ENSG00000160216, ENSG00000175894, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421273