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Basic information

CohesinDB ID: CDBP00421274

Locus: chr21-45447735-45461753

Data sourse: GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, GSE121355, GSE131606, GSE25021, ENCSR000EDW, GSE115602, ENCSR000EFJ, ENCSR000BTU, ENCSR917QNE, GSE165895, GSE67783, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR635OSG, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE38411

Cell type: MCF-7, Macrophage, RPE, Hela-Kyoto, Fibroblast, HCT-116, Hep-G2, MB157, Ishikawa, RT-112, IMR-90, HSPC, K-562, BCBL-1, Liver, HFFc6, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 20% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 19%, "7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, TEAD1, LMO2, OCA2, MED26, SOX5, ZNF528, RFX3, GATAD2A, JARID2, ZNF263, POU5F1, TOP2A, CTBP1, STAT1, SAP130, ERG, EZH1, SMARCA4, RFX1, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, DRAP1, MXI1, RUNX1, ZMYM2, CEBPA, NKX2-2, HDAC1, CRY1, TET2, TBX3, SP5, SMARCC1, ZXDC, SOX11, SP2, SMARCB1, PIAS1, NR1H2, C11orf30, STAT5A, IKZF5, ARID2, RBM25, ZNF605, MBD2, ETV4, CBFA2T2, CREM, PAF1, SS18, NFATC1, WT1, MPHOSPH8, JUNB, ZFP36, MAF1, PLAG1, ZBTB6, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, SCRT1, ILF3, ADNP, ZNF316, FOSL1, SMARCA2, HNF1A, KDM4B, PBX2, TSC22D4, THRB, ATF3, ZFP64, RUNX3, CBFB, TP63, MITF, JMJD1C, ELF1, RBM39, CTCF, JUN, L3MBTL4, MNT, DPF2, ZNF280A, TFAP2C, MLX, RBPJ, ZNF317, ZBTB48, NONO, SRF, CHD4, PBX1, ONECUT1, HOMEZ, FOXP2, RXRA, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, CCAR2, TBL1XR1, KLF8, ARHGAP35, GRHL2, EBF3, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, SOX13, AFF4, POU4F2, ZNF18, ARNT, BACH1, ZNF48, PBX3, NCAPH2, HMGXB4, TEAD3, U2AF1, USF1, SP1, TFAP2A, BCL11A, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, TRP47, AGO1, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF830, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, ZNF141, TP53, ZNF334, PHF5A, KAT8, EGR1, TFIIIC, RNF2, BRD4, JUND, CUX1, SMAD4.1D12, ZNF468, PGR, SOX2, PATZ1, TFAP4, CHD7, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, SOX4, TRIM24, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, SP4, TBP, HNF4G, OGG1, ETS1, MYC, ARID1B, NKX2-1, MCRS1, GABPA, STAT3, DNMT3B, INO80, SRSF3, EZH2, ZNF652, NFE2L1, PHF8, ZNF436, SPI1, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, SIN3A, ERG3, CREBBP, ZNF384, RARA, NFYC, TAF15, SMAD4, CDK8, ZEB1, ZMYM3, GTF3C2, SREBF2, RBM22, MAFK, HNF4A, REST, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, HDAC6, TCF7, FOXO3, RELA, TARDBP, MAX, NR2F1, TCF7L2, NEUROG2, KDM5B, PKNOX1, MYOD1, AR, YAP1, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, MEIS2, RBFOX2, ZNF28, ZFHX2, ZNF90, INSM2, NFIC, CTCFL, MECOM, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, E2F1, FOXA3, ZNF175, ATRX, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ZNF300, ASCL1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, TFE3, IRF1, ZGPAT, ZNF766, MRTFB, PTBP1, CBX1, SMC1A, MAFG, SIRT6, FIP1L1, ZFX, SMAD3, TWIST1, PRPF4, NOTCH1, RUNX2, GR, ZNF184, NRF1, PBX4, FOS, CHD1, TGIF2, MED1, CEBPD, KDM6B, MYB, SCRT2, ZNF3, SETDB1, NIPBL, PHF20, ZBTB7A, TCF3, SKI, FOXA2, RBBP5, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, GATA1, HAND2, CEBPG, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZNF579, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): TSPEAR,FAM207A,COL18A1,ITGB2-AS1,ADARB1,POFUT2,TRAPPC10,PCBP3,ITGB2,SUMO3,UBE2G2

Function elements

Human SNPs: Triglycerides

Number of somatic mutations (coding): 658

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000160218, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421274