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Basic information

CohesinDB ID: CDBP00421275

Locus: chr21-45463590-45484721

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 65% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.244

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 25%, "7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: MBD3, FOXO1, NFIA, FOSL1, PGR, TRIM25, HMG20A, SOX2, HNF1A, FOXA1, RBFOX2, RXRB, PBX2, ZFHX2, KDM3A, TFAP4, TSC22D4, ATF3, THRB, NFIC, ZFP64, HNRNPUL1, ZNF362, RUNX3, CHD7, CBFB, MXD4, PAX5, TP63, MITF, CDX2, ELF1, TRIM28, TEAD1, RBM39, SNAI2, KLF6, KLF10, RCOR2, ESR1, HNF1B, PITX3, USF2, CTCF, TCF12, JUN, EP300, L3MBTL4, MNT, SOX5, DPF2, E2F6, DMAP1, U2AF2, ZNF528, RFX3, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, TFAP2C, MLX, JARID2, PDX1, POU2F2, CHD8, BRD1, MYCN, ZNF263, HHEX, ID3, ZBTB17, ZBTB48, STAT1, NONO, GATAD1, SAP130, ARID3A, TBP, HNF4G, ERG, PBX1, ASCL1, OGG1, ZNF341, ETS1, MYC, ZBTB8A, SMARCA4, HOMEZ, TOP1, RAD21, GRHL3, ARID1B, RXRA, NKX2-1, FOXK2, GABPA, MCRS1, STAT3, XRCC5, ZNF614, PRDM14, IKZF1, RCOR1, DNMT3B, HNRNPH1, NR2F6, MIER3, TCF25, NR3C1, ESRRA, CEBPB, INO80, HNRNPL, KMT2A, CREB1, CCAR2, EZH2, TBL1XR1, GRHL2, FEZF1, ZNF652, EBF3, GABPB1, ZHX2, HES1, TFE3, MIXL1, HBP1, ZSCAN2, PCBP1, HDAC2, GATA2, SSRP1, ZNF644, GATAD2B, MXD3, SREBF1, HCFC1, ZGPAT, DRAP1, MXI1, NR2C2, NFIL3, RUVBL2, MYF5, PTBP1, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SIRT6, FIP1L1, ZFX, SOX13, SIN3A, SMAD3, ZNF770, TET2, ERG3, TBX3, SP5, SMARCC1, TWIST1, MYBL2, CREBBP, RARA, PRPF4, NFYC, TAF15, ZNF384, RUNX2, ZNF35, GATA4, OSR2, NRF1, ARNT, ZBTB10, ZNF48, PRDM9, SMAD4, FOXM1, FOS, CHD1, HMGXB4, TGIF2, SMARCB1, MED1, CDK8, TEAD3, TERF1, KDM6B, ZEB1, CEBPD, U2AF1, ZNF3, MBD1, ZNF22, RBM22, USF1, SP1, NIPBL, MAFK, HNF4A, BCL11A, IKZF5, ARID2, ZBTB7A, REST, ARID1A, ASH2L, HNRNPLL, PHIP, TCF3, FOXP1, GLIS2, PRDM6, AATF, SMC3, STAG1, MLLT1, ETV4, NFATC3, SKI, TRP47, CBFA2T2, MEF2B, PPARG, AGO1, FOXA2, EBF1, CHD2, SS18, CREM, ZNF600, MIER2, ZNF692, WT1, MAFF, ESR2, FOXF1, ZBTB33, TCF7, CDK9, ZNF580, ZKSCAN1, FOXO3, KDM1A, YY1, RELA, CREB3L1, TARDBP, NEUROD1, SP140, TCF4, HIF1A, ZIC2, GATA3, MAX, NRIP1, ZNF143, AGO2, GATA1, HAND2, PLAG1, CEBPG, NR2F2, NR2F1, NEUROG2, KDM5B, TCF7L2, TP53, ZBTB6, PKNOX1, RUVBL1, ZNF334, MYOD1, EGR2, ELF3, PHF5A, KAT8, ARID4B, AR, NFKBIZ, BHLHE40, RXR, ZBTB42, HEXIM1, EGR1, HSF1, ZBTB26, IKZF2, BRD4, RNF2, JUND, ILF3, CUX1, MAZ, SMAD4.1D12, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): POFUT2,FAM207A,ADARB1,TSPEAR,ITGB2,UBE2G2,PCBP3,ITGB2-AS1,COL18A1,TRAPPC10,SUMO3

Function elements

Human SNPs: HDL_cholesterol_levels

Number of somatic mutations (coding): 1869

Number of somatic mutations (non-coding): 409

Related genes and loops

Related gene: ENSG00000160218, ENSG00000175894, ENSG00000184787, ENSG00000184900, ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421275