Deatailed information for cohesin site CDBP00421277

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  • Basic information
  • CohesinDB ID: CDBP00421277
  • Locus: chr21-45487915-45502397
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR404BPV, GSE105028, GSE103477, GSE131606, GSE108869, GSE25021, ENCSR917QNE, GSE115602, GSE165895, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000BMY, ENCSR635OSG, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE83726, GSE126990, GSE50893, GSE126755, GSE131577
  • Cell type: MDM, RH4, Liver, H9-hESC, RPE, Fibroblast, GM12890, HeLa-S3, K-562, HFFc6, DKO, H1-hESC, SNYDER, MB157, GM12878, RT-112, Macrophage, MCF-7, Hela-Kyoto, HCT-116, HL-60, Hep-G2, Neurons-H1, Neutrophil, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 18% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.722
  • Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 40%, "4_Tx": 24%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, ZNF468, FOSL1, TRIM25, E2F7, SOX2, PATZ1, SUZ12, RBFOX2, ZNF28, ZFHX2, HNRNPK, HDGF, ATF3, ZFP64, THAP1, ZBTB44, CHD7, CBFB, ZNF189, TP63, CDC5L, ZNF467, JMJD1C, MAF, KLF5, RBM39, SNAI2, LMO2, ESR1, CTCF, DPF2, TRIM24, ZNF528, TEAD4, GTF2F1, RBPJ, TFAP2C, GLIS1, NANOG, ZSCAN5D, MYCN, ZNF263, POU5F1, TOP2A, ZBTB48, STAT1, SRF, TBP, ZNF300, ERG, OGG1, ZNF341, MYC, KDM4A, RAD21, GRHL3, GABPA, STAT3, XRCC5, ZNF614, PRDM14, DNMT3B, HNRNPH1, HNRNPL, KMT2A, EZH2, BMPR1A, GRHL2, FEZF1, GABPB1, ZHX2, SPI1, ZNF257, KLF17, PCBP1, ZNF182, MXD3, HCFC1R1, ZNF76, ETV5, RUNX1, BCL6, SIRT6, ZFX, SMAD3, ERG3, CREBBP, ZNF35, NOTCH1, TAF15, ARNT, ZNF48, ATF2, SMAD4, PRDM9, NCAPH2, SUPT5H, FOS, CHD1, TEAD3, KDM6B, ZNF264, ZNF558, SMAD1, ZNF3, RBM22, ARID2, ZBTB7A, ASH2L, HNRNPLL, GLIS2, BCOR, AATF, STAG1, CXXC4, NFATC3, TRP47, CBFA2T2, FOXA2, AGO1, RBBP5, EBF1, PAF1, CHD2, ZNF600, ZNF692, ZSCAN16, WT1, ZNF30, ZBTB33, CDK9, KDM1A, YY1, RELA, TARDBP, BRG1, MCM3, SP140, ZIC2, HIF1A, MAX, ZNF143, AGO2, PLAG1, ZFP69B, BCL11B, TCF7L2, KDM5B, TP53, ZNF334, AR, RXR, HEXIM1, EGR1, RB1, HSF1, ZBTB26, TFIIIC, SCRT1, BRD4, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): FAM207A,CFAP410,TRPM2,ADARB1,COL18A1,COL6A2,PFKL
  • Function elements
  • Human SNPs: Platelet_distribution_width
  • Number of somatic mutations (coding): 1921
  • Number of somatic mutations (non-coding): 588
  • Related genes and loops
  • Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000142173,
  • Related loop: chr21:44325000-44350000~~chr21:45500000-45525000, chr21:44975000-45000000~~chr21:45500000-45525000, chr21:45125000-45150000~~chr21:45500000-45525000, chr21:45325000-45350000~~chr21:45500000-45525000, chr21:45500000-45525000~~chr21:46100000-46125000,
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