Deatailed information for cohesin site CDBP00421278

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  • Basic information
  • CohesinDB ID: CDBP00421278
  • Locus: chr21-45502617-45502900
  • Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE206145-NatGen2015, ENCSR153HNT
  • Cell type: MCF-7, Fibroblast, HCT-116, K-562, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 1% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.944
  • Subunit: Mau2,SA1,Rad21,SA2
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 84% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 56%, "15_Quies": 28%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, ZNF468, TRIM25, PGR, FOSL1, HMGN3, NME2, MEIS2, XBP1, PATZ1, FOXA1, SUZ12, RBFOX2, LEO1, RXRB, PBX2, ZFHX2, HNRNPK, ZBTB7B, HDGF, ZNF90, ATF3, THRB, BMI1, ZFP64, INSM2, RUNX3, PRDM1, ZNF444, KLF14, CBFB, MXD4, ZNF189, PAX5, TP63, ZSCAN4, ZNF736, CDC5L, JMJD1C, ZNF629, MAF, TEAD1, TRIM28, ZNF573, RBM39, ETV1, BCLAF1, KLF10, ZNF217, ESR1, ELF1, OCA2, USF2, CTCF, TCF12, JUN, SND1, KLF1, E4F1, ZBTB20, MNT, PAX8, DPF2, RYBP, E2F6, TRIM24, IRF4, E2F4, ZNF410, ZNF512B, ZNF528, POU2F2, GATAD2A, GTF2F1, TFAP2C, RBPJ, EHMT2, JARID2, GLIS1, YBX1, NANOG, PDX1, BRD1, ZSCAN5D, MYCN, POU5F1, ZNF263, TOP2A, ID3, CTBP1, MTA2, ZBTB48, ZSCAN5A, STAT1, DUX4, NONO, SRF, SAP130, DDX5, HIC1, NBN, PHB2, ERG2, ERG, HOXC5, OGG1, ZNF341, MYC, ZNF25, SMARCA4, RFX1, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, ZNF614, ZNF8, PRDM14, IKZF1, DNMT3B, HNRNPH1, NR2F6, VDR, ZNF639, NR3C1, ZNF750, ESRRA, CEBPB, HNRNPL, CREB1, CCAR2, EZH2, TBL1XR1, KLF8, ARHGAP35, GRHL2, FEZF1, GABPB1, ZHX2, IRF1, ZNF257, PCBP1, HDAC2, SSRP1, GATAD2B, MXD3, FLI1, HCFC1, SMARCA5, ZNF490, RELB, NFIL3, NFYB, NCOA2, ETV5, PTBP1, RUNX1, BCL6, SMC1A, HDAC1, SIRT6, SIN3A, ZFX, AFF4, POU4F2, SOX13, SMAD3, PCBP2, TET2, ERG3, ZNF473, ZNF18, NSD2, ZBTB2, CREBBP, NOTCH1, RARA, TAF15, OSR2, GR, ZNF184, ARNT, NFIB, ZBTB10, ZNF48, SMAD4, ZEB2, PBX3, SP2, FOS, CHD1, SUPT5H, SMARCB1, MED1, TEAD3, ZEB1, KDM6B, MYB, ZNF558, ZMYM3, SCRT2, ZNF3, KLF9, NCOA1, SETDB1, RBM22, USF1, SP1, BCL11A, PHF20, ARID2, IKZF5, ZBTB7A, ZNF479, REST, ATF7, HNRNPLL, EED, GLIS2, TCF3, ZNF684, BCOR, AATF, PRDM6, SMC3, STAG1, MLLT1, NFATC3, SKI, TRP47, CBFA2T2, KLF13, AGO1, FOXA2, EBF1, CBX3, PAF1, NFATC1, ZNF600, ZSCAN16, MTA3, WT1, ZNF692, ZBTB33, CDK9, BCL3, MPHOSPH8, KDM1A, YY1, RELA, ZKSCAN1, TARDBP, KLF7, JUNB, BRG1, SP140, ZIC2, HIF1A, BATF, TAL1, MAX, NRIP1, GATA1, AGO2, ZNF143, PLAG1, CBX2, KLF4, BCL11B, NCOA3, NR2F2, NR2F1, ZNF791, KDM5B, TP53, ZNF687, PKNOX1, ZNF334, EGR2, RBM14, BHLHE40, AR, ZNF445, EGLN2, ZBTB42, HEXIM1, EGR1, ZNF366, HSF1, ZBTB26, NCOR1, BRD4, JUND, IKZF2, CLOCK, CUX1, MAZ, SCRT1, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): PFKL,TRPM2,CFAP410,COL18A1,ADARB1,FAM207A,COL6A2
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 0
  • Related genes and loops
  • Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000142173,
  • Related loop: chr21:44325000-44350000~~chr21:45500000-45525000, chr21:44975000-45000000~~chr21:45500000-45525000, chr21:45125000-45150000~~chr21:45500000-45525000, chr21:45325000-45350000~~chr21:45500000-45525000, chr21:45500000-45525000~~chr21:46100000-46125000,
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