Deatailed information for cohesin site CDBP00421279

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  • Basic information
  • CohesinDB ID: CDBP00421279
  • Locus: chr21-45503606-45519118
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE25021, ENCSR000BUC, ENCSR917QNE, GSE165895, ENCSR000BTU, ENCSR000DZP, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE126755, GSE38411
  • Cell type: RH4, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, IMR-90, K-562, BCBL-1, HFFc6, DKO, H1-hESC, MB157, GM12878, SK-N-SH, RT-112, Macrophage, HUES64, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, Neutrophil, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 20% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.711
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TES,Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 84% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 36%, "4_Tx": 23%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, MORC2, PAX5, SFPQ, TEAD1, LMO2, OCA2, ZNF507, E4F1, SOX5, PAX8, ZNF407, E2F4, DEK, NR5A2, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, CTBP1, ZMYND11, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, RFX1, DNMT1, ZNF8, ZNF398, RCOR1, DACH1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, MXD3, FLI1, HCFC1, NR2C2, DRAP1, RELB, HCFC1R1, RUVBL2, RUNX1, HDAC1, CEBPA, ZNF707, CRY1, TET2, ZNF473, SP5, TRIM22, PRDM10, ZBTB2, ZXDC, ELK1, ZBTB10, SOX11, ATF2, ZNF354A, FOXM1, SMARCB1, GMEB1, PIAS1, NR1H2, C11orf30, STAT5A, ARID2, IKZF5, RBM25, AFF1, MBD2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, WT1, MEF2C, MPHOSPH8, NEUROD1, JUNB, TCF4, ZNF311, BATF, MAF1, PLAG1, KLF4, BCL11B, IRF5, MED, EGR2, RBM14, ELF3, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF621, XBP1, PBX2, SRSF4, HNRNPK, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, TP63, CDC5L, MAF, JMJD1C, ELF1, RBM39, SNAI2, SMAD5, ZIK1, FUS, CTCF, JUN, L3MBTL4, MNT, LMO1, DPF2, ZNF776, ZNF280A, TFAP2C, RBPJ, YBX1, ZNF239, MTA2, ZBTB17, ZBTB48, NONO, SRF, UTX, DDX5, NBN, PHB2, ONECUT1, ZNF2, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, KLF8, ARHGAP35, GRHL2, EBF3, SSRP1, ZNF146, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, AFF4, ZNF770, SP3, ARNT, NFIB, BACH1, ZNF48, PRDM9, ZEB2, PBX3, ETV6, ZNF10, NCAPH2, TEAD3, ZNF680, USF1, BCL11A, SP1, TFAP2A, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAG1, MLLT1, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF645, ZNF334, NFKB1, PHF5A, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, PGR, CBX5, PATZ1, LEO1, TFAP4, BMI1, CHD7, ZNF444, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX9, E2F6, TRIM24, PRKDC, GTF2F1, GLIS1, POU2F2, CDK9-HEXIM1, ZSCAN5D, ZBTB1, ZSCAN5A, ERG2, SP4, HIC1, HNF4G, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, SPI1, PCBP1, HDAC2, GATAD2B, ZNF490, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, NFXL1, CREBBP, RARA, ZNF384, ZNF35, TAF15, SMAD4, CBFA2T3, CDK8, SNRNP70, CSNK2A1, ZEB1, ZMYM3, NCOA1, SREBF2, ZNF22, RBM22, MAFK, HNF4A, REST, ARID1A, HNRNPLL, BCOR, FOXP1, AATF, PPARG, ZNF692, ZNF30, ZNF662, FOXO3, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, NR2F1, ZNF791, KDM5B, TCF7L2, PKNOX1, AR, KMT2D, HEXIM1, AHR, FOSL2, MBD3, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, ZNF90, INSM2, NFIC, CTCFL, ZBTB5, PRDM1, ZNF736, HDAC3, CDX2, TRIM28, BCLAF1, ETV1, ZNF26, USF2, TCF12, EP300, BAF155, GATA6, ZNF302, GLI4, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, GATAD1, ZNF300, ASCL1, MIER1, USP7, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, FEZF1, TRPS1, HES1, TFE3, HBP1, IRF1, ZGPAT, PTBP1, SMC1A, MAFG, CBX1, SIRT6, FIP1L1, ZFX, ZNF534, SMAD3, PCBP2, PRPF4, NOTCH1, CDK6, GATA4, OSR2, ZNF184, GR, NRF1, PBX4, NR2C1, SUPT5H, FOS, CHD1, MED1, KDM6B, CEBPD, SCRT2, MYB, ZNF3, L3MBTL2, ZNF136, SETDB1, NIPBL, ZBTB7A, CCNT2, TCF3, SKI, NCOA4, FOXA2, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, HIF1A, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, ZNF837, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): TRPM2,CFAP410,COL18A1,PFKL,ADARB1,FAM207A,SLC19A1,COL6A2
  • Function elements
  • Human SNPs: Blood_protein_levels
  • Number of somatic mutations (coding): 2332
  • Number of somatic mutations (non-coding): 595
  • Related genes and loops
  • Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000142173,
  • Related loop: chr21:44325000-44350000~~chr21:45500000-45525000, chr21:44975000-45000000~~chr21:45500000-45525000, chr21:45125000-45150000~~chr21:45500000-45525000, chr21:45325000-45350000~~chr21:45500000-45525000, chr21:45500000-45525000~~chr21:46100000-46125000, chr21:45514977-45516574~~chr21:45540779-45543029,
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