- Basic information
- CohesinDB ID: CDBP00421280
- Locus: chr21-45522806-45526243
-
Data sourse: ENCSR167MTG, ENCSR338DUC, GSE206145-GSE177045, ENCSR230ZWH, GSE67783, GSE72082, GSE165895, GSE86191, GSE116868, ENCSR000EGW, GSE111913, GSE76893, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR054FKH, ENCSR153HNT, GSE25021, ENCSR917QNE
-
Cell type: MCF-7, RPE, Fibroblast, HCT-116, Hep-G2, MB157, RT-112, K-562, Liver, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 43%,
"4_Tx": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: NFIA, NME2, XBP1, FOXA1, RBFOX2, LEO1, ATF3, NFIC, TP63, TRIM28, ESR1, OCA2, HDAC8, CTCF, JUN, BAF155, TFAP2C, EED, GLIS1, CHD8, MYCN, POU5F1, TOP2A, KDM4C, ZNF263, ZBTB48, ZSCAN5A, MLLT3, ERG, MYC, EZH1, GRHL3, GABPA, DNMT3B, ZNF750, EZH2, GRHL2, GATA2, MXD3, RUNX1, ZFX, TET2, ZNF18, TAF15, OSR2, NFIB, ZNF708, ZNF48, SUPT5H, KDM6B, ZNF680, PIAS1, ZNF3, RBM22, BCL11A, GSPT2, ZBTB7A, POU2F3, ASH2L, FOXP1, AATF, SMC3, STAG1, TRP47, AGO1, FOXA2, EBF1, PAF1, ZNF600, WT1, HOXB13, KDM1A, YY1, RELA, TARDBP, SP140, MAX, ZNF143, AGO2, PLAG1, NCOA3, NR2F1, TP53, AR, PAX3-FOXO1, HEXIM1, HSF1, ZBTB26, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PCBP3,FAM207A,CFAP410,TRPM2,PFKL,SLC19A1,COL6A2,ADARB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 220
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000160256,
ENSG00000197381,
ENSG00000173638,
ENSG00000183570,
ENSG00000142173,
- Related loop:
chr21:44325000-44350000~~chr21:45500000-45525000,
chr21:44325000-44350000~~chr21:45525000-45550000,
chr21:44975000-45000000~~chr21:45500000-45525000,
chr21:45125000-45150000~~chr21:45500000-45525000,
chr21:45125000-45150000~~chr21:45525000-45550000,
chr21:45325000-45350000~~chr21:45500000-45525000,
chr21:45500000-45525000~~chr21:46100000-46125000,
chr21:45525000-45550000~~chr21:45800000-45825000,