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Basic information

CohesinDB ID: CDBP00421282

Locus: chr21-45549108-45549455

Data sourse: ENCSR167MTG, GSE67783, GSE72082, ENCSR054FKH, ENCSR153HNT

Cell type: K-562, HSPC, Hep-G2

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 35%, "14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF195, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, IKZF3, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, ARID5B, SOX5, PAX8, ZNF407, E2F4, ZNF674, DEK, ZNF410, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, ZNF263, TOP2A, BRD3, CTBP1, ZMYND11, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, DNMT1, TOP1, FOXK2, ZNF8, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, ZNF785, HCFC1, NR2C2, RELB, HCFC1R1, EP400, RUVBL2, RUNX1, CEBPA, HDAC1, NKX2-2, CRY1, TET2, TBX3, ZNF473, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, IKZF5, ARID2, RBM25, MBD2, ZNF337, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, SS18, WT1, MEF2C, NEUROD1, JUNB, MCM3, ZFP36, TCF4, ZNF311, BATF, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, IRF5, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZBTB26, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, ZNF621, XBP1, KDM4B, PBX2, HNRNPK, THRB, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, BACH2, CDC5L, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, JUN, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, ZNF280A, PDX1, RBPJ, MLX, TFAP2C, YBX1, ZNF239, ZSCAN21, MTA2, ZBTB48, ZBTB17, ZNF317, NONO, SRF, DDX5, NBN, PHB2, CHD4, PBX1, KDM4A, HOMEZ, FOXP2, ZNF2, TSHZ1, RXRA, BATF3, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, CCAR2, TBL1XR1, KLF8, ARHGAP35, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, SMARCA5, NFIL3, THAP11, ZNF585A, EZH2phosphoT487, LDB1, SOX13, AFF4, POU4F2, ZNF747, ZNF770, ZNF18, SP3, ARNT, NFIB, BACH1, DAXX, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ETV6, HMGXB4, TEAD3, DIDO1, ZXDB, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, KLF7, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, CBX2, TP53, ZNF334, NFKB1, PHOX2B, PHF5A, BRD2, KAT8, TBX21, ZNF430, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, ZNF468, PGR, PATZ1, LEO1, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, TP73, ZNF524, SND1, KLF1, SOX9, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZBTB1, ZSCAN5A, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, ARID1B, PHF21A, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, SRSF3, YBX3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, ATM, ZNF490, NCOA2, ZNF76, ETV5, BCL6, SIN3A, ERG3, NFXL1, MEF2A, RARA, NFYC, ZNF384, CREBBP, TAF15, ZNF35, SMAD4, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, ZNF692, GTF2B, ZNF662, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF223, ZNF592, GFI1B, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, T, AR, YAP1, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, MBD3, HMG20A, E2F7, HMGN3, SUZ12, RBFOX2, ZFHX2, ZNF90, INSM2, NFIC, ZBTB5, CTCFL, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, TCF12, EP300, BAF155, GATA6, GLI4, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, ZNF649, MLLT3, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, ZNF341, MCM5, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, ARNTL, HES1, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZFX, ZNF335, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, PBX4, NR2C1, SUPT5H, FOS, CHD1, TGIF2, MED1, ZNF7, KDM6B, CEBPD, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, PAX7, ZNF283, NCOA4, KLF13, NELFA, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, BHLHE22, ZNF519, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PFKL,ADARB1,CFAP410,TRPM2,PCBP3,SLC19A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000197381, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421282