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Basic information

CohesinDB ID: CDBP00421283

Locus: chr21-45549738-45561026

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 82% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.167

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TSS,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 20%, "2_TssAFlnk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF426, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, PITX3, HDAC8, ZNF561, E4F1, ZNF157, SOX5, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, POU5F1, ZNF263, CTBP1, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, SMARCA4, TOP1, FOXK2, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, ZNF785, NR2C2, RELB, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, ZNF654, TBX3, TET2, SP5, TRIM22, SMARCC1, ZNF549, PRDM10, ZBTB2, ELK1, ZBTB10, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, IKZF5, ARID2, ZSCAN31, MBD2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, PAF1, WT1, CREB3L1, NEUROD1, JUNB, MCM3, ZFP36, TCF4, BATF, MAF1, ZNF333, PLAG1, KLF4, BCL11B, ZFP69B, ZNF281, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, ILF3, FOSL1, ZNF660, XBP1, HNF1A, ZNF101, KDM4B, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, ZNF273, ZSCAN4, TP63, MITF, ZNF467, MAF, JMJD1C, INTS11, ELF1, RBM39, KLF10, FUS, CTCF, TAF3, JUN, L3MBTL4, MNT, ZBTB20, RYBP, DPF2, IRF4, ZNF423, TFAP2C, RBPJ, MLX, MTA2, ZSCAN21, ZBTB48, ZBTB17, NONO, SRF, NBN, CHD4, ONECUT1, KDM4A, ZNF2, FOXP2, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, EZH2phosphoT487, SOX13, AFF4, ZNF770, ZMIZ1, ZNF18, SP3, NFIB, BACH1, ARNT, DAXX, ZNF48, ZEB2, NFYA, PBX3, NCAPH2, MAFB, HMGXB4, TEAD3, ZXDB, ZNF680, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, ZKSCAN1, KDM1A, KLF7, ZNF441, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, MTA1, AGO2, CBX2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, CUX1, ZSCAN23, TBX2, ZNF468, PGR, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, OGG1, ETS1, MYC, ARID1B, ZNF24, PHF21A, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, GFI1, DNMT3B, INO80, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF777, ZNF76, ZNF554, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, CREBBP, ZNF384, RARA, NFYC, ZNF35, TAF15, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, NCOA1, SREBF2, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, ZNF543, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, ZNF791, PKNOX1, ZNF547, RUVBL1, AR, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, CTCFL, PRDM1, KLF14, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, COBLL1, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, CREB3, SOX6, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, GATAD1, GMEB2, ARID3A, USP7, MIER1, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, TCF25, ZNF639, ZNF750, JMJD6, TFE3, HBP1, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, SMAD2, PBX4, NRF1, NR2C1, CHD1, SUPT5H, FOS, TGIF2, MED1, KDM6B, MYB, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ZNF610, SP140, HIF1A, OTX2, ZNF519, HAND2, CEBPG, SP7, NR2F2, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): CFAP410,COL6A2,POFUT2,PCBP3,ADARB1,TRPM2,SLC19A1,PFKL

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 70

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000197381, ENSG00000186866, ENSG00000173638, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421283