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Basic information

CohesinDB ID: CDBP00421285

Locus: chr21-45569935-45572811

Data sourse: GSE67783, GSE86191, GSE115248, ENCSR000BLY, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX, GSE165895

Cell type: Fibroblast, HCT-116, Kelly, SK-N-SH, K-562, HSPC, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 40%, "15_Quies": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, HLF, SUZ12, PBX2, ZNF28, ELF1, TEAD1, ZNF573, RBM39, PITX3, CTCF, TCF12, EP300, RFX5, TEAD4, CHD8, BRD1, MYCN, ZBTB48, MYC, SMARCA4, RAD21, GABPA, STAT3, XRCC5, RCOR1, NR3C1, CEBPB, SRSF3, KMT2A, EZH2, EBF3, GATA2, MXD3, FLI1, MXI1, HCFC1R1, ETV5, RUNX1, SMC1A, EZH2phosphoT487, ZFX, SMAD3, TET2, SMARCC1, TWIST1, ZNF384, RUNX2, GATA4, PBX3, FOS, TEAD3, ZEB1, KDM6B, MAFK, USF1, HNF4A, REST, TCF3, STAG1, NFATC3, TRP47, FOXA2, MTA3, CHD2, SS18, ZNF600, WT1, BCL3, KDM1A, YY1, RELA, NEUROD1, BRG1, ISL1, MCM3, TCF4, ZIC2, SP140, OTX2, GATA3, HAND2, CBX2, ZFP69B, GFI1B, NR2F2, NR2F1, ZNF334, PHOX2B, BHLHE40, AR, MAML3, HSF1, BRD4, JUND, MAZ, TBX2, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): ADARB1,PCBP3,POFUT2,COL6A2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 21

Related genes and loops

Related gene: ENSG00000197381, ENSG00000186866, ENSG00000183570, ENSG00000142173,

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Deatailed information for cohesin site CDBP00421285