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Basic information

CohesinDB ID: CDBP00421286

Locus: chr21-45573733-45582416

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE105028, GSE121355, GSE25021, GSE131606, GSE165895, GSE93080, GSE67783, GSE86191, GSE206145-NatGen2015, ENCSR703TNG, GSE206145, ENCSR000BTQ, GSE110061, GSE129526, GSE111913, ENCSR153HNT

Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, GM12878, RT-112, HSPC, SK-N-SH, K-562, Liver, HFFc6, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 30%, "15_Quies": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, PGR, FOSL1, HMGN3, SOX2, XBP1, FOXA1, SUZ12, MLL4, ZFHX2, ZNF28, ATF3, NFIC, CBFB, PAX5, TP63, MITF, TEAD1, TRIM28, ELF1, RBM39, NFE2L2, LMO2, ESR1, USF2, JUN, CTCF, TCF12, BAF155, EP300, MNT, GATA6, DPF2, E2F6, TRIM24, SOX6, E2F4, E2F1, NR5A2, SMC1, ZNF350, TEAD4, GTF2F1, TFAP2C, JARID2, GLIS1, ZNF263, MYCN, TOP2A, POU5F1, RUNX1T1, ZBTB48, ZSCAN5A, STAT1, MLLT3, SRF, ERG2, ERG, ZNF329, ASCL1, OGG1, MYC, MCM5, SMARCA4, EOMES, RAD21, GRHL3, PROX1, NKX2-1, RXRA, GABPA, STAT3, XRCC5, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, NFE2, NR3C1, KMT2A, CREB1, EZH2, GRHL2, GABPB1, HDAC2, GATA2, ZNF182, FLI1, HCFC1R1, PTBP1, ETV5, RUNX1, SMC1A, CBX1, HDAC1, EZH2phosphoT487, SIRT6, ZFX, ZNF534, SMAD3, ZNF770, ERG3, TET2, SMARCC1, PRDM10, TWIST1, ZNF18, CREBBP, NOTCH1, TAF15, GATA4, NRF1, ARNT, NFIB, ZBTB10, BACH1, SMAD4, CBFA2T3, SP2, FOS, CHD1, MED1, ZNF584, ZEB1, KDM6B, CEBPD, ZMYM3, PIAS1, ZNF3, KLF9, L3MBTL2, SETDB1, USF1, MAFK, TFAP2A, BCL11A, HNF4A, REST, RBM25, HNRNPLL, ZNF548, CTBP2, GLIS2, TCF3, MBD2, AATF, SMC3, STAG1, TRP47, CBFA2T2, ZNF316, FOXA2, SS18, ZNF600, WT1, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, NEUROD1, BRG1, MCM3, SP140, ZIC2, HIF1A, GATA3, KLF15, TAL1, MAX, MAF1, NRIP1, ZNF143, GATA1, HAND2, PLAG1, CBX2, NR2F2, NR2F1, KDM5B, TP53, ZNF687, PKNOX1, ZNF334, MYOD1, EGR2, T, BHLHE40, AR, ZNF579, RXR, HEXIM1, TFIIIC, HSF1, ZBTB26, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): COL6A2,PCBP3,POFUT2,ADARB1

Function elements

Human SNPs: Protein_quantitative_trait_loci_(liver)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 63

Related genes and loops

Related gene: ENSG00000197381, ENSG00000186866, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421286