- Basic information
- CohesinDB ID: CDBP00421299
- Locus: chr21-45614607-45619741
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE131606, GSE25021, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR338DUC, GSE130140, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, ENCSR000BTQ, ENCSR167MTG, GSE111913, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755
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Cell type: RH4, GM2610, CUTLL1, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, K-562, DKO, H1-hESC, SNYDER, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, MCF-7, GM12892, HCT-116, Hep-G2, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.711
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 25%,
"13_ReprPC": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, CBX5, PGR, ZNF660, ZSCAN5C, SOX2, MEIS2, NME2, XBP1, TBL1X, PATZ1, FOXA1, SUZ12, PBX2, ZFHX2, HDGF, TSC22D4, ATF3, NFIC, BMI1, INSM2, ZFP64, ZBTB5, RUNX3, IKZF3, ATF4, CBFB, ZNF189, PAX5, TP63, MITF, ZNF320, BACH2, MAF, JMJD1C, KLF5, ELF1, BCLAF1, TRIM28, RBM39, ETV1, ZNF629, NFE2L2, ZNF217, ESR1, OCA2, PITX3, ZNF561, CTCF, TCF12, SND1, JUN, E4F1, ARID5B, MNT, LMO1, EP300, ZBTB20, DPF2, KLF1, E2F6, IRF4, TRIM24, ZNF423, E2F1, KMT2B, GTF2F1, EHMT2, TFAP2C, EED, RBPJ, GLIS1, POU2F2, CHD8, ZSCAN5D, MYCN, ZNF263, TOP2A, CDK7, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN21, STAT1, ZNF317, SRF, MLLT3, DDX5, NBN, SAP130, ARID3A, ERG2, ERG, ASCL1, OGG1, ZNF341, ZBTB8A, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, APC, XRCC5, STAT3, ZNF398, IKZF1, RCOR1, HNRNPH1, DNMT3B, ZNF639, VDR, NFE2, NR3C1, CEBPB, SRSF3, STAT5B, KMT2A, CREB1, EZH2, KLF8, GRHL2, EBF3, GABPB1, SPI1, IRF1, KLF17, HDAC2, INTS13, GATAD2B, MXD3, SIX2, FLI1, HCFC1, MXI1, SMARCA5, RELB, HCFC1R1, MRTFB, NCOA2, ZNF76, ZNF554, ATF1, RUNX1, SMC1A, BCL6, HDAC1, EZH2phosphoT487, NKX2-2, CBX1, SIN3A, ZFX, ZNF335, CEBPA, SMAD3, TET2, CBX8, ERG3, ZNF770, TRIM22, SMARCC1, TWIST1, PRDM10, MEF2A, ZBTB2, ZNF384, NOTCH1, CREBBP, TAF15, ZNF35, RUNX2, HMBOX1, OSR2, ZNF184, ARNT, NRF1, BACH1, NFIB, ATF2, ZNF48, ZEB2, SMAD4, ZNF518A, PBX3, FOXM1, ETV6, FOS, SUPT5H, HMGXB4, CDK8, CHD1, MED1, SMARCB1, TEAD3, ZEB1, KDM6B, MYB, ZNF558, U2AF1, SMAD1, ZNF331, KLF9, C11orf30, L3MBTL2, MAFG, HIF2A, USF1, SP1, BCL11A, TFAP2A, MAFK, REST, ZBTB7A, ZSCAN31, ATF7, ASH2L, HNRNPLL, ZNF548, PHIP, BCOR, TCF3, GLIS2, PRDM6, AATF, SMC3, NCOR2, MLLT1, STAG1, NFATC3, ZNF394, TRP47, MEF2B, ZNF316, ZNF207, MTA3, FOXA2, EBF1, SS18, CREM, ZNF600, CHD2, ZBED1, WT1, ZNF692, MAFF, ZNF574, ZBTB33, MEF2C, CDK9, BCL3, YY1, RELA, TARDBP, JUNB, NEUROD1, BRG1, MCM3, SP140, ZIC2, SKIL, HIF1A, ZFP36, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, HAND2, CBX2, PLAG1, ZFP69B, ZNF592, BCL11B, GFI1B, NCOA3, SP7, CEBPG, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, ZSCAN22, MYOD1, EGR2, NFKB1, TBX21, ARID4B, BHLHE40, AR, TAF1, ZBTB40, RXR, ZNF324, ZNF366, EGR1, RB1, HEXIM1, HSF1, RNF2, IKZF2, BRD4, NOTCH3, JUND, CLOCK, CUX1, MAZ, ZSCAN23, TBX2, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): COL6A2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 32
- Related genes and loops