- Basic information
- CohesinDB ID: CDBP00421305
- Locus: chr21-45629009-45638293
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Data sourse: GSE206145-GSE177045, GSE72082, GSE132649, GSE116868, ENCSR000BLY, GSE25021, GSE131606, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, GSE86191, GSE206145-NatGen2015, GSE120943, GSE98367, GSE206145, ENCSR000EHX, GSE111913, ENCSR153HNT, GSE126755, GSE38411
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Cell type: MCF-7, RPE, T-47D, Fibroblast, HCT-116, Monocytes, MB157, GM12878, RT-112, K-562, SK-N-SH, BCBL-1, Neutrophil, HSPC, Macrophage, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.822
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 27%,
"15_Quies": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, XBP1, FOXA1, SUZ12, HDGF, ATF3, ZBTB5, RUNX3, CBFB, PAX5, TP63, MITF, JMJD1C, BCLAF1, TRIM28, ESR1, OCA2, TP73, CTCF, JUN, TCF12, LMO1, GATA6, DPF2, ZNF528, GTF2F1, RBPJ, EED, TFAP2C, GLIS1, POU2F2, CHD8, ZNF263, MYCN, CDK7, RUNX1T1, POU5F1, MTA2, ZBTB48, STAT1, ERG, PBX1, OGG1, MYC, EZH1, SMARCA4, GRHL3, GABPA, STAT3, PRDM14, IKZF1, NFE2, DNMT3B, NR3C1, KMT2A, EZH2, BMPR1A, GABPB1, SPI1, ZNF257, GATA2, FLI1, HCFC1, SMARCA5, RELB, HCFC1R1, NCOA2, RUNX1, BCL6, EZH2phosphoT487, LDB1, ZFX, TET2, ERG3, CREBBP, NOTCH1, ZNF133, CDK6, FOS, CHD1, SMARCB1, SUPT5H, MED1, ZEB1, MYB, ZNF680, SCRT2, SETDB1, MAFK, BCL11A, REST, ZNF479, HNRNPLL, TCF3, ZNF684, BCOR, AATF, SMC3, STAG1, MLLT1, ZNF283, TRP47, MEF2B, FOXA2, EBF1, ZNF600, GTF2B, WT1, ZBTB33, YY1, RELA, NEUROD1, BRG1, MCM3, SP140, ZIC2, HIF1A, ZNF311, GATA3, TAL1, MAX, NRIP1, ZNF143, GATA1, PLAG1, CBX2, BCL11B, NR2F1, TP53, ZNF687, ZNF334, BHLHE40, AR, TAF1, ZBTB40, RXR, HEXIM1, HSF1, NCOR1, BRD4, SCRT1, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PFKL,TRPM2,COL6A2,CFAP410,PCBP3,TSPEAR
- Function elements
- Human SNPs: Educational_attainment_(years_of_education)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 105
- Related genes and loops
- Related gene:
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000175894,
ENSG00000183570,
ENSG00000142173,
- Related loop:
chr21:29675000-29700000~~chr21:45600000-45625000,
chr21:44325000-44350000~~chr21:45625000-45650000,
chr21:44475000-44500000~~chr21:45625000-45650000,
chr21:45554287-45556966~~chr21:45642028-45644331,
chr21:45600000-45625000~~chr21:46100000-46125000,
chr21:45614591-45616251~~chr21:45631522-45633445,
chr21:45625000-45650000~~chr21:45750000-45775000,
chr21:45625000-45650000~~chr21:46050000-46075000,
chr21:45625000-45650000~~chr21:46100000-46125000,
chr21:45640592-45641966~~chr21:45767982-45769723,
chr21:45640683-45641855~~chr21:45817841-45819035,