- Basic information
- CohesinDB ID: CDBP00421313
- Locus: chr21-45694886-45695654
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000FAD, ENCSR000BSB, GSE126634, ENCSR000BLY, GSE105028, GSE121355, GSE25021, ENCSR000EDW, ENCSR000BUC, ENCSR000EFJ, ENCSR000BTU, GSE93080, ENCSR000DZP, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE135093, GSE152721, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE116344, GSE145327, GSE94872, ENCSR000EEG, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR748MVX, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE131956, GSE129526, ENCSR335RKQ, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS
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Cell type: RH4, GM2610, CVB-hiPSC, HSPC, CVI-hiPSC, HuCC-T1, H9-hESC, GM2630, HMEC, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, GM18526, H1-hESC, GM18951, GM12878, GM12891, GM2588, GBM39, SK-N-SH, HeLa-Tet-On, GM19193, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, GM19238, HAP1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 24% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.589
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 74%,
"14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, CHD8, SMC1A, FOXA2, TOP2A, NME2, XBP1, GTF2B, DUX4, SMAD3, FOXA1, SRF, SUZ12, BAHD1, RELA, CREBBP, ZBTB2, ZNF35, RAD21, ARNT, HIF1A, SOX11, ZNF48, SMC3, GABPA, PAX5, NRIP1, SUPT5H, CDK8, MIER3, ZNF143, NFE2, MED1, ARNTL, TEAD3, NCOA3, SMAD1, EZH2, ESR1, ZNF334, ZNF140, CTCF, AR, ZBTB40, GATA2, IKZF5, FLI1, NCOR1, SCRT1, FOXP1, NCOA2, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): ADARB1,COL6A2,PCBP3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 3
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000197381,
ENSG00000183570,
ENSG00000142173,
- Related loop:
chr21:45200000-45225000~~chr21:45675000-45700000,
chr21:45325000-45350000~~chr21:45675000-45700000,
chr21:45550000-45575000~~chr21:45700000-45725000,
chr21:45675000-45700000~~chr21:45800000-45825000,
chr21:45675000-45700000~~chr21:45875000-45900000,
chr21:45675000-45700000~~chr21:45900000-45925000,
chr21:45675000-45700000~~chr21:46050000-46075000,
chr21:45675000-45700000~~chr21:46100000-46125000,
chr21:45694422-45696402~~chr21:45819564-45821784,
chr21:45694441-45696331~~chr21:45819765-45821570,
chr21:45694441-45696331~~chr21:45879486-45881477,
chr21:45694513-45696084~~chr21:45819806-45821569,
chr21:45694552-45696040~~chr21:45819886-45821571,
chr21:45694618-45696100~~chr21:45818578-45821540,
chr21:45700000-45725000~~chr21:45900000-45925000,