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Basic information

CohesinDB ID: CDBP00421323

Locus: chr21-45724221-45724921

Data sourse: GSE72082, GSE86191, GSE115250, ENCSR000BLY, ENCSR000EHW, GSE206145-NatGen2015, ENCSR153HNT, ENCSR000EHX, GSE83726, GSE116344

Cell type: MCF-7, Fibroblast, RH4, HCT-116, SK-N-SH, K-562, TC-32

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SMC3,Rad21,SA1,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 43%, "14_ReprPCWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, XBP1, FOXA1, ZFHX2, ATF3, TP63, KLF5, TEAD1, ESR1, OCA2, PITX3, CTCF, DPF2, E2F6, TFAP2C, RBPJ, GLIS1, POU2F2, CHD8, MYCN, ZNF263, POU5F1, KDM4C, ZBTB48, DDX5, ERG2, ERG, OGG1, ZNF341, MYC, SMARCA4, RAD21, GRHL3, PROX1, STAT3, IKZF1, RCOR1, NR3C1, KMT2A, CCAR2, EZH2, EBF3, PCBP1, FLI1, MXI1, NCOA2, RUNX1, SMC1A, EZH2phosphoT487, CRY1, ZFX, SMAD3, TET2, ERG3, TWIST1, CREBBP, GATA4, ARNT, PRDM9, NR2C1, CDK8, MED1, ZEB1, KLF9, SP1, REST, ZNF479, AATF, SMC3, MLLT1, STAG1, TRP47, CBFA2T2, TBL1X, ZNF600, WT1, ZBTB33, KDM1A, YY1, RELA, NEUROD1, SP140, ZIC2, HIF1A, OTX2, GATA3, MAX, NRIP1, ZNF143, HAND2, NCOA3, NR2F2, NR2F1, NEUROG2, TP53, MYOD1, EGR2, T, AR, PAX3-FOXO1, HEXIM1, HSF1, BRD4, SCRT1, CLOCK, MAZ

Target gene symbol (double-evidenced CRMs): PCBP3,SLC19A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 5

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421323